Emerging Biological Principles of Metastasis
Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastat...
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| Format: | Article |
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/116968 https://orcid.org/0000-0002-0895-3557 |
| _version_ | 1826217017531695104 |
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| author | Lambert, Arthur W. Pattabiraman, Diwakar R. Weinberg, Robert A |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Lambert, Arthur W. Pattabiraman, Diwakar R. Weinberg, Robert A |
| author_sort | Lambert, Arthur W. |
| collection | MIT |
| description | Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge. |
| first_indexed | 2024-09-23T16:56:44Z |
| format | Article |
| id | mit-1721.1/116968 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:56:44Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1169682022-10-03T09:20:27Z Emerging Biological Principles of Metastasis Lambert, Arthur W. Pattabiraman, Diwakar R. Weinberg, Robert A Massachusetts Institute of Technology. Department of Biology Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology) Weinberg, Robert A Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge. 2018-07-13T13:26:48Z 2018-07-13T13:26:48Z 2017-02 2018-07-12T14:48:32Z Article http://purl.org/eprint/type/JournalArticle 0092-8674 1097-4172 http://hdl.handle.net/1721.1/116968 Lambert, Arthur W. et al. “Emerging Biological Principles of Metastasis.” Cell 168, 4 (February 2017): 670–691 © 2017 Elsevier Inc https://orcid.org/0000-0002-0895-3557 http://dx.doi.org/10.1016/J.CELL.2016.11.037 Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Lambert, Arthur W. Pattabiraman, Diwakar R. Weinberg, Robert A Emerging Biological Principles of Metastasis |
| title | Emerging Biological Principles of Metastasis |
| title_full | Emerging Biological Principles of Metastasis |
| title_fullStr | Emerging Biological Principles of Metastasis |
| title_full_unstemmed | Emerging Biological Principles of Metastasis |
| title_short | Emerging Biological Principles of Metastasis |
| title_sort | emerging biological principles of metastasis |
| url | http://hdl.handle.net/1721.1/116968 https://orcid.org/0000-0002-0895-3557 |
| work_keys_str_mv | AT lambertarthurw emergingbiologicalprinciplesofmetastasis AT pattabiramandiwakarr emergingbiologicalprinciplesofmetastasis AT weinbergroberta emergingbiologicalprinciplesofmetastasis |