Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression
The epithelial-mesenchymal transition (EMT) program has emerged as a central driver of tumor malignancy. Moreover, the recently uncovered link between passage through an EMT and acquisition of stem-like properties indicates that activation of the EMT programs serves as a major mechanism for generati...
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/116975 https://orcid.org/0000-0002-0895-3557 |
| _version_ | 1826210954027728896 |
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| author | Ye, Xin Weinberg, Robert A |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Ye, Xin Weinberg, Robert A |
| author_sort | Ye, Xin |
| collection | MIT |
| description | The epithelial-mesenchymal transition (EMT) program has emerged as a central driver of tumor malignancy. Moreover, the recently uncovered link between passage through an EMT and acquisition of stem-like properties indicates that activation of the EMT programs serves as a major mechanism for generating cancer stem cells (CSCs); that is, a subpopulation of cancer cells that are responsible for initiating and propagating the disease. In this review, we summarize the evidence supporting the widespread involvement of the EMT program in tumor pathogenesis and attempt to rationalize the connection between the EMT program and acquisition of stem cell traits. We propose that epithelial-mesenchymal plasticity is likely controlled by multiple varients of the core EMT program, and foresee the need to resolve the various programs and the molecular mechanisms that underlie them. |
| first_indexed | 2024-09-23T14:58:04Z |
| format | Article |
| id | mit-1721.1/116975 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:58:04Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1169752022-09-29T11:46:10Z Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression Ye, Xin Weinberg, Robert A Massachusetts Institute of Technology. Department of Biology Weinberg, Robert A The epithelial-mesenchymal transition (EMT) program has emerged as a central driver of tumor malignancy. Moreover, the recently uncovered link between passage through an EMT and acquisition of stem-like properties indicates that activation of the EMT programs serves as a major mechanism for generating cancer stem cells (CSCs); that is, a subpopulation of cancer cells that are responsible for initiating and propagating the disease. In this review, we summarize the evidence supporting the widespread involvement of the EMT program in tumor pathogenesis and attempt to rationalize the connection between the EMT program and acquisition of stem cell traits. We propose that epithelial-mesenchymal plasticity is likely controlled by multiple varients of the core EMT program, and foresee the need to resolve the various programs and the molecular mechanisms that underlie them. Breast Cancer Research Foundation Samuel Waxman Cancer Research Foundation Massachusetts Institute of Technology. Ludwig Center for Cancer Research National Cancer Institute (U.S.).(Program P01-CA080111) National Cancer Institute (U.S.).(Program R01-CA078461) National Cancer Institute (U.S.).(Program U01-CA184897) 2018-07-13T15:16:59Z 2018-07-13T15:16:59Z 2015-11 2018-07-12T17:01:37Z Article http://purl.org/eprint/type/JournalArticle 09628924 http://hdl.handle.net/1721.1/116975 Ye, Xin, and Robert A. Weinberg. “Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression.” Trends in Cell Biology 25, no. 11 (November 2015): 675–686. https://orcid.org/0000-0002-0895-3557 http://dx.doi.org/10.1016/J.TCB.2015.07.012 Trends in Cell Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Ye, Xin Weinberg, Robert A Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression |
| title | Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression |
| title_full | Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression |
| title_fullStr | Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression |
| title_full_unstemmed | Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression |
| title_short | Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression |
| title_sort | epithelial mesenchymal plasticity a central regulator of cancer progression |
| url | http://hdl.handle.net/1721.1/116975 https://orcid.org/0000-0002-0895-3557 |
| work_keys_str_mv | AT yexin epithelialmesenchymalplasticityacentralregulatorofcancerprogression AT weinbergroberta epithelialmesenchymalplasticityacentralregulatorofcancerprogression |