Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

Studying cancer metabolism gives insight into tumorigenic survival mechanisms and susceptibilities. In melanoma, we identify HEXIM1, a transcription elongation regulator, as a melanoma tumor suppressor that responds to nucleotide stress. HEXIM1 expression is low in melanoma. Its overexpression in a...

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Bibliographic Details
Main Authors: Tan, Justin L., Fogley, Rachel D., Flynn, Ryan A., Ablain, Julien, Yang, Song, Do, Brian T., Laga, Alvaro C., Fujinaga, Koh, Santoriello, Cristina, Greer, Celeste B., Kim, Yoon Jung, Clohessy, John G., Bothmer, Anne, Pandell, Nicole, Avagyan, Serine, Brogie, John E., van Rooijen, Ellen, Hagedorn, Elliott J., Shyh-Chang, Ng, White, Richard M., Price, David H., Pandolfi, Pier Paolo, Peterlin, B. Matija, Zhou, Yi, Kim, Tae Hoon, Asara, John M., Chang, Howard Y., Zon, Leonard I., Saint-André, Violaine, Fan, Zi Peng, Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116990
https://orcid.org/0000-0001-8855-8647

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