A team effort: natural killer cells on the first leg of the tumor immunity relay race
Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tum...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Biomed Central Ltd.
2018
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| Online Access: | http://hdl.handle.net/1721.1/117046 https://orcid.org/0000-0002-4015-7112 |
| _version_ | 1811083990074916864 |
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| author | Fessenden, Timothy B Duong, Ellen Spranger-Zimmermann, Stefani |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Fessenden, Timothy B Duong, Ellen Spranger-Zimmermann, Stefani |
| author_sort | Fessenden, Timothy B |
| collection | MIT |
| description | Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tumor immunity. This work highlights the cooperative nature of anti-tumor immunity set in motion by Natural Killer cells, and immune evasion by tumors through their exclusion. |
| first_indexed | 2024-09-23T12:42:50Z |
| format | Article |
| id | mit-1721.1/117046 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:42:50Z |
| publishDate | 2018 |
| publisher | Biomed Central Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/1170462022-09-28T09:37:10Z A team effort: natural killer cells on the first leg of the tumor immunity relay race Fessenden, Timothy B Duong, Ellen Spranger-Zimmermann, Stefani Massachusetts Institute of Technology. Department of Biology Duong, Ellen Spranger-Zimmermann, Stefani Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tumor immunity. This work highlights the cooperative nature of anti-tumor immunity set in motion by Natural Killer cells, and immune evasion by tumors through their exclusion. National Cancer Institute (U.S.) (R00CA204595) 2018-07-23T18:09:35Z 2018-07-23T18:09:35Z 2018-07 2018-04 2018-07-15T03:27:12Z Article http://purl.org/eprint/type/JournalArticle 2051-1426 http://hdl.handle.net/1721.1/117046 Fessenden, Timothy B., et al. “A Team Effort: Natural Killer Cells on the First Leg of the Tumor Immunity Relay Race.” Journal for ImmunoTherapy of Cancer, vol. 6, no. 1, Dec. 2018. © 2018 The Author(s) https://orcid.org/0000-0002-4015-7112 en https://doi.org/10.1186/s40425-018-0380-4 Journal for ImmunoTherapy of Cancer Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ The Author(s). application/pdf Biomed Central Ltd. BioMed Central |
| spellingShingle | Fessenden, Timothy B Duong, Ellen Spranger-Zimmermann, Stefani A team effort: natural killer cells on the first leg of the tumor immunity relay race |
| title | A team effort: natural killer cells on the first leg of the tumor immunity relay race |
| title_full | A team effort: natural killer cells on the first leg of the tumor immunity relay race |
| title_fullStr | A team effort: natural killer cells on the first leg of the tumor immunity relay race |
| title_full_unstemmed | A team effort: natural killer cells on the first leg of the tumor immunity relay race |
| title_short | A team effort: natural killer cells on the first leg of the tumor immunity relay race |
| title_sort | team effort natural killer cells on the first leg of the tumor immunity relay race |
| url | http://hdl.handle.net/1721.1/117046 https://orcid.org/0000-0002-4015-7112 |
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