Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals
Objectives: Obesity is an important risk factor for the development of colorectal cancer (CRC). Although the impact of bariatric surgery on CRC is conflicting, its impact on precursor lesions is unknown. The aim of this study was to determine whether bariatric surgery before index screening colonosc...
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| Format: | Article |
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Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/1721.1/117052 https://orcid.org/0000-0001-6093-7282 https://orcid.org/0000-0002-7577-4612 |
| _version_ | 1826199222240673792 |
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| author | Kedrin, Dmitriy Gandhi, Shaan-Chirag Chandrahas Wolf, Molly Roper, Jatin Yilmaz, Omer Corey, Kathleen Khalili, Hamed Stanford, Fatima Cody Gala, Manish |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Kedrin, Dmitriy Gandhi, Shaan-Chirag Chandrahas Wolf, Molly Roper, Jatin Yilmaz, Omer Corey, Kathleen Khalili, Hamed Stanford, Fatima Cody Gala, Manish |
| author_sort | Kedrin, Dmitriy |
| collection | MIT |
| description | Objectives: Obesity is an important risk factor for the development of colorectal cancer (CRC). Although the impact of bariatric surgery on CRC is conflicting, its impact on precursor lesions is unknown. The aim of this study was to determine whether bariatric surgery before index screening colonoscopy is associated with decreased development of colorectal adenomas. Methods: We performed a retrospective cohort study of bariatric surgery patients who had undergone index, screening colonoscopy at an academic center from 2001 to 2014. Patients who had bariatric surgery at least 1 year before index colonoscopy were compared with those who had surgery after colonoscopy, using multivariable logistic regression to control for presurgical body mass index, sex, gender, race, type of surgery, aspirin use, metformin use, smoking, and age at colonoscopy. Results: One hundred and twenty-five obese individuals who had bariatric surgery before colonoscopy were compared with 223 individuals who had colonoscopy after surgery. Adenomatous polyps were found in 16.8% of individuals who had surgery first vs. 35.5% who had colonoscopy before bariatric surgery (unadjusted odds ratio (OR) 0.37, 95% confidence interval (CI): 0.21-0.64, P=0.0003). After multivariable adjustment, bariatric surgery before index screening colonoscopy was associated with a decreased risk of adenomas at index colonoscopy (adjusted OR 0.37, 95% CI: 0.19-0.69, P=0.002). Conclusions: Bariatric surgery is associated with a decreased risk of colorectal adenomas in obese individuals without a family history of CRC. |
| first_indexed | 2024-09-23T11:16:40Z |
| format | Article |
| id | mit-1721.1/117052 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:16:40Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1170522022-09-27T18:23:40Z Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals Kedrin, Dmitriy Gandhi, Shaan-Chirag Chandrahas Wolf, Molly Roper, Jatin Yilmaz, Omer Corey, Kathleen Khalili, Hamed Stanford, Fatima Cody Gala, Manish Koch Institute for Integrative Cancer Research at MIT Kedrin, Dmitriy Roper, Jatin Yilmaz, Omer Objectives: Obesity is an important risk factor for the development of colorectal cancer (CRC). Although the impact of bariatric surgery on CRC is conflicting, its impact on precursor lesions is unknown. The aim of this study was to determine whether bariatric surgery before index screening colonoscopy is associated with decreased development of colorectal adenomas. Methods: We performed a retrospective cohort study of bariatric surgery patients who had undergone index, screening colonoscopy at an academic center from 2001 to 2014. Patients who had bariatric surgery at least 1 year before index colonoscopy were compared with those who had surgery after colonoscopy, using multivariable logistic regression to control for presurgical body mass index, sex, gender, race, type of surgery, aspirin use, metformin use, smoking, and age at colonoscopy. Results: One hundred and twenty-five obese individuals who had bariatric surgery before colonoscopy were compared with 223 individuals who had colonoscopy after surgery. Adenomatous polyps were found in 16.8% of individuals who had surgery first vs. 35.5% who had colonoscopy before bariatric surgery (unadjusted odds ratio (OR) 0.37, 95% confidence interval (CI): 0.21-0.64, P=0.0003). After multivariable adjustment, bariatric surgery before index screening colonoscopy was associated with a decreased risk of adenomas at index colonoscopy (adjusted OR 0.37, 95% CI: 0.19-0.69, P=0.002). Conclusions: Bariatric surgery is associated with a decreased risk of colorectal adenomas in obese individuals without a family history of CRC. National Institutes of Health (U.S.) (Grant T32-DK007191) 2018-07-23T18:57:07Z 2018-07-23T18:57:07Z 2017-02 2016-10 2018-07-13T15:58:30Z Article http://purl.org/eprint/type/JournalArticle 2155-384X http://hdl.handle.net/1721.1/117052 Kedrin, Dmitriy et al. “Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals.” Clinical and Translational Gastroenterology 8, 2 (February 2017): e73 © 2017 the American College of Gastroenterology https://orcid.org/0000-0001-6093-7282 https://orcid.org/0000-0002-7577-4612 http://dx.doi.org/10.1038/ctg.2017.1 Clinical and Translational Gastroenterology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Nature Publishing Group Nature |
| spellingShingle | Kedrin, Dmitriy Gandhi, Shaan-Chirag Chandrahas Wolf, Molly Roper, Jatin Yilmaz, Omer Corey, Kathleen Khalili, Hamed Stanford, Fatima Cody Gala, Manish Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals |
| title | Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals |
| title_full | Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals |
| title_fullStr | Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals |
| title_full_unstemmed | Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals |
| title_short | Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals |
| title_sort | bariatric surgery prior to index screening colonoscopy is associated with a decreased rate of colorectal adenomas in obese individuals |
| url | http://hdl.handle.net/1721.1/117052 https://orcid.org/0000-0001-6093-7282 https://orcid.org/0000-0002-7577-4612 |
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