MicroRNA Control of TGF-β Signaling
Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small regulatory RNAs that are approximately 22 nucleotides long, which direct the post-transcriptional regulation of diverse targe...
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| Format: | Article |
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MDPI AG
2018
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| Online Access: | http://hdl.handle.net/1721.1/117139 |
| _version_ | 1811071679070208000 |
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| author | Suzuki, Hiroshi |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Suzuki, Hiroshi |
| author_sort | Suzuki, Hiroshi |
| collection | MIT |
| description | Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small regulatory RNAs that are approximately 22 nucleotides long, which direct the post-transcriptional regulation of diverse target genes and control cell states. Transforming growth factor (TGF)-β; family is a multifunctional cytokine family, which plays many regulatory roles in the development and pathogenesis of diverse diseases, including fibrotic disease, cardiovascular disease and cancer. Previous studies have shown that the TGF-β; pathway includes the miRNA pathway as an important component of its downstream signaling cascades. Multiple studies of epithelial–mesenchymal transition (EMT)-related miRNAs have highlighted that miRNAs constitute the intrinsic bistable molecular switches of cell states by forming double negative feedback loops with EMT-inducing transcription factors. This may be important for understanding the reversibility of EMT at the single-cell level, the presence of distinct EMT transition states and the intra- and inter-tumor heterogeneity of cancer cell phenotypes. In the present review, I summarize the connection between TGF-β; signaling and the miRNA pathway, placing particular emphasis on the regulation of miRNA expression by TGF-β; signaling, the modulation of TGF-β; signaling by miRNAs, the miRNA-mediated modulation of EMT and endothelial–mesenchymal transition as well as the crosstalk between miRNA and TGF-β; pathways in the tumor microenvironment. |
| first_indexed | 2024-09-23T08:54:56Z |
| format | Article |
| id | mit-1721.1/117139 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:54:56Z |
| publishDate | 2018 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/1171392022-09-30T12:07:43Z MicroRNA Control of TGF-β Signaling Suzuki, Hiroshi Koch Institute for Integrative Cancer Research at MIT Suzuki, Hiroshi Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small regulatory RNAs that are approximately 22 nucleotides long, which direct the post-transcriptional regulation of diverse target genes and control cell states. Transforming growth factor (TGF)-β; family is a multifunctional cytokine family, which plays many regulatory roles in the development and pathogenesis of diverse diseases, including fibrotic disease, cardiovascular disease and cancer. Previous studies have shown that the TGF-β; pathway includes the miRNA pathway as an important component of its downstream signaling cascades. Multiple studies of epithelial–mesenchymal transition (EMT)-related miRNAs have highlighted that miRNAs constitute the intrinsic bistable molecular switches of cell states by forming double negative feedback loops with EMT-inducing transcription factors. This may be important for understanding the reversibility of EMT at the single-cell level, the presence of distinct EMT transition states and the intra- and inter-tumor heterogeneity of cancer cell phenotypes. In the present review, I summarize the connection between TGF-β; signaling and the miRNA pathway, placing particular emphasis on the regulation of miRNA expression by TGF-β; signaling, the modulation of TGF-β; signaling by miRNAs, the miRNA-mediated modulation of EMT and endothelial–mesenchymal transition as well as the crosstalk between miRNA and TGF-β; pathways in the tumor microenvironment. 2018-07-26T17:29:39Z 2018-07-26T17:29:39Z 2018-06 2018-06 2018-07-25T12:41:05Z Article http://purl.org/eprint/type/JournalArticle 1422-0067 http://hdl.handle.net/1721.1/117139 Suzuki, Hiroshi. "MicroRNA Control of TGF-β Signaling." International Journal of Molecular Sciences 19, 7 (June 2018): 1901 © 2018 The Author http://dx.doi.org/10.3390/ijms19071901 International Journal of Molecular Sciences Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf MDPI AG Multidisciplinary Digital Publishing Institute |
| spellingShingle | Suzuki, Hiroshi MicroRNA Control of TGF-β Signaling |
| title | MicroRNA Control of TGF-β Signaling |
| title_full | MicroRNA Control of TGF-β Signaling |
| title_fullStr | MicroRNA Control of TGF-β Signaling |
| title_full_unstemmed | MicroRNA Control of TGF-β Signaling |
| title_short | MicroRNA Control of TGF-β Signaling |
| title_sort | microrna control of tgf β signaling |
| url | http://hdl.handle.net/1721.1/117139 |
| work_keys_str_mv | AT suzukihiroshi micrornacontroloftgfbsignaling |