Mechanical properties of crosslinks controls failure mechanism of hierarchical intermediate filament networks
Intermediate filaments are one of the key components of the cytoskeleton in eukaryotic cells, and their mechanical properties are found to be equally important for physiological function and disease. While the mechanical properties of single full length filaments have been studied, how the mechanica...
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/117169 https://orcid.org/0000-0002-4173-9659 |
| _version_ | 1811076441716031488 |
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| author | Qin, Zhao Buehler, Markus J |
| author2 | Massachusetts Institute of Technology. Center for Computational Engineering |
| author_facet | Massachusetts Institute of Technology. Center for Computational Engineering Qin, Zhao Buehler, Markus J |
| author_sort | Qin, Zhao |
| collection | MIT |
| description | Intermediate filaments are one of the key components of the cytoskeleton in eukaryotic cells, and their mechanical properties are found to be equally important for physiological function and disease. While the mechanical properties of single full length filaments have been studied, how the mechanical properties of crosslinks affect the mechanical property of the intermediate filament network is not well understood. This paper applies a mesoscopic model of the intermediate network with varied crosslink strengths to investigate its failure mechanism under the extreme mechanical loading. It finds that relatively weaker crosslinks lead to a more flaw tolerant intermediate filament network that is also 23% stronger than the one with strong crosslinks. These findings suggest that the mechanical properties of interfacial components are critical for bioinspired designs which provide intriguing mechanical properties. Key words: failure mechanism; flow tolerance; intermediate filament; protein network; soft material; rupture; crosslink strength; bioinspired design |
| first_indexed | 2024-09-23T10:22:13Z |
| format | Article |
| id | mit-1721.1/117169 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:22:13Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1171692022-09-26T17:26:18Z Mechanical properties of crosslinks controls failure mechanism of hierarchical intermediate filament networks Qin, Zhao Buehler, Markus J Massachusetts Institute of Technology. Center for Computational Engineering Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Qin, Zhao Buehler, Markus J Intermediate filaments are one of the key components of the cytoskeleton in eukaryotic cells, and their mechanical properties are found to be equally important for physiological function and disease. While the mechanical properties of single full length filaments have been studied, how the mechanical properties of crosslinks affect the mechanical property of the intermediate filament network is not well understood. This paper applies a mesoscopic model of the intermediate network with varied crosslink strengths to investigate its failure mechanism under the extreme mechanical loading. It finds that relatively weaker crosslinks lead to a more flaw tolerant intermediate filament network that is also 23% stronger than the one with strong crosslinks. These findings suggest that the mechanical properties of interfacial components are critical for bioinspired designs which provide intriguing mechanical properties. Key words: failure mechanism; flow tolerance; intermediate filament; protein network; soft material; rupture; crosslink strength; bioinspired design 2018-07-27T18:06:00Z 2018-07-27T18:06:00Z 2012-01 2011-10 2018-07-27T17:04:07Z Article http://purl.org/eprint/type/JournalArticle 2095-0349 http://hdl.handle.net/1721.1/117169 Qin, Zhao and Markus J. Buehler. "Theoretical and Applied Mechanics Letters." Theoretical and Applied Mechanics Letters 2, 1 (January 2012): 014005. © 2012 The Chinese Society of Theoretical and Applied Mechanics https://orcid.org/0000-0002-4173-9659 http://dx.doi.org/10.1063/2.1201405 Theoretical and Applied Mechanics Letters Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Qin, Zhao Buehler, Markus J Mechanical properties of crosslinks controls failure mechanism of hierarchical intermediate filament networks |
| title | Mechanical properties of crosslinks controls failure mechanism of hierarchical intermediate filament networks |
| title_full | Mechanical properties of crosslinks controls failure mechanism of hierarchical intermediate filament networks |
| title_fullStr | Mechanical properties of crosslinks controls failure mechanism of hierarchical intermediate filament networks |
| title_full_unstemmed | Mechanical properties of crosslinks controls failure mechanism of hierarchical intermediate filament networks |
| title_short | Mechanical properties of crosslinks controls failure mechanism of hierarchical intermediate filament networks |
| title_sort | mechanical properties of crosslinks controls failure mechanism of hierarchical intermediate filament networks |
| url | http://hdl.handle.net/1721.1/117169 https://orcid.org/0000-0002-4173-9659 |
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