Short- and long-term effects of chromosome mis-segregation and aneuploidy
Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased...
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/1721.1/117201 https://orcid.org/0000-0002-1501-6190 https://orcid.org/0000-0001-9837-0314 |
| _version_ | 1811077166868201472 |
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| author | Santaguida, Stefano Amon, Angelika B |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Santaguida, Stefano Amon, Angelika B |
| author_sort | Santaguida, Stefano |
| collection | MIT |
| description | Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased proliferative potential. These contradictory effects are also observed in mouse models of chromosome instability (CIN). CIN can inhibit and promote tumorigenesis. Recent work has provided insights into the cellular consequences of CIN and aneuploidy. Chromosome mis-segregation per se can alter the genome in many more ways than just causing the gain or loss of chromosomes. The short- and long-term effects of aneuploidy are caused by gene-specific effects and a stereotypic aneuploidy stress response. Importantly, these recent findings provide insights into the role of aneuploidy in tumorigenesis. |
| first_indexed | 2024-09-23T10:38:54Z |
| format | Article |
| id | mit-1721.1/117201 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:38:54Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1172012022-09-30T22:02:11Z Short- and long-term effects of chromosome mis-segregation and aneuploidy Santaguida, Stefano Amon, Angelika B Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Amon A Santaguida, Stefano Amon, Angelika B Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased proliferative potential. These contradictory effects are also observed in mouse models of chromosome instability (CIN). CIN can inhibit and promote tumorigenesis. Recent work has provided insights into the cellular consequences of CIN and aneuploidy. Chromosome mis-segregation per se can alter the genome in many more ways than just causing the gain or loss of chromosomes. The short- and long-term effects of aneuploidy are caused by gene-specific effects and a stereotypic aneuploidy stress response. Importantly, these recent findings provide insights into the role of aneuploidy in tumorigenesis. National Institutes of Health (U.S.) (Grant GM56800) 2018-07-30T18:15:42Z 2018-07-30T18:15:42Z 2015-07 Article http://purl.org/eprint/type/JournalArticle 1471-0072 1471-0080 http://hdl.handle.net/1721.1/117201 Santaguida, Stefano and Angelika Amon. “Short- and Long-Term Effects of Chromosome Mis-Segregation and Aneuploidy.” Nature Reviews Molecular Cell Biology 16, 8 (August 2015): 473–485 https://orcid.org/0000-0002-1501-6190 https://orcid.org/0000-0001-9837-0314 en_US https://doi.org/10.1038/nrm4025 Nature Reviews Molecular Cell Biology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group Prof. Amon via Courtney Crummett |
| spellingShingle | Santaguida, Stefano Amon, Angelika B Short- and long-term effects of chromosome mis-segregation and aneuploidy |
| title | Short- and long-term effects of chromosome mis-segregation and aneuploidy |
| title_full | Short- and long-term effects of chromosome mis-segregation and aneuploidy |
| title_fullStr | Short- and long-term effects of chromosome mis-segregation and aneuploidy |
| title_full_unstemmed | Short- and long-term effects of chromosome mis-segregation and aneuploidy |
| title_short | Short- and long-term effects of chromosome mis-segregation and aneuploidy |
| title_sort | short and long term effects of chromosome mis segregation and aneuploidy |
| url | http://hdl.handle.net/1721.1/117201 https://orcid.org/0000-0002-1501-6190 https://orcid.org/0000-0001-9837-0314 |
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