Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments
Intermediate filaments (often abbreviated as IFs), in addition to microtubules and microfilaments, are one of the three major components of the cytoskeleton in eukaryotic cells (Figure 1). It has been suggested that intermediate filaments are crucial in defining key mechanical functions of cells suc...
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| Format: | Article |
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ASME International
2018
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| Online Access: | http://hdl.handle.net/1721.1/117221 https://orcid.org/0000-0002-4173-9659 |
| _version_ | 1811097930237476864 |
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| author | Bertaud, Jérémie Buehler, Markus J |
| author2 | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Bertaud, Jérémie Buehler, Markus J |
| author_sort | Bertaud, Jérémie |
| collection | MIT |
| description | Intermediate filaments (often abbreviated as IFs), in addition to microtubules and microfilaments, are one of the three major components of the cytoskeleton in eukaryotic cells (Figure 1). It has been suggested that intermediate filaments are crucial in defining key mechanical functions of cells such as cell migration, cell division and mechanotransduction, and have also been referred to as the “safety belts of cells” reflecting their role in preventing exceedingly large cell stretch [1, 2]. Vimentin is a specific type of this protein filament found in fibroblasts, leukocytes, and blood vessel endothelial cells, representing the most widely distributed type of intermediate filaments. Several diseases have been linked to the structure and density of intermediate filaments. Here we report a systematic study of the effects of intermediate filaments on cell mechanics, specifically focused on changes in the density of filaments. We compare the results with experimental studies in vimentin deficient cells, showing good qualitative agreement. |
| first_indexed | 2024-09-23T17:07:14Z |
| format | Article |
| id | mit-1721.1/117221 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T17:07:14Z |
| publishDate | 2018 |
| publisher | ASME International |
| record_format | dspace |
| spelling | mit-1721.1/1172212024-07-15T17:39:06Z Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments Bertaud, Jérémie Buehler, Markus J Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics Buehler, Markus J Intermediate filaments (often abbreviated as IFs), in addition to microtubules and microfilaments, are one of the three major components of the cytoskeleton in eukaryotic cells (Figure 1). It has been suggested that intermediate filaments are crucial in defining key mechanical functions of cells such as cell migration, cell division and mechanotransduction, and have also been referred to as the “safety belts of cells” reflecting their role in preventing exceedingly large cell stretch [1, 2]. Vimentin is a specific type of this protein filament found in fibroblasts, leukocytes, and blood vessel endothelial cells, representing the most widely distributed type of intermediate filaments. Several diseases have been linked to the structure and density of intermediate filaments. Here we report a systematic study of the effects of intermediate filaments on cell mechanics, specifically focused on changes in the density of filaments. We compare the results with experimental studies in vimentin deficient cells, showing good qualitative agreement. 2018-07-31T16:16:03Z 2018-07-31T16:16:03Z 2010-02 2018-07-27T17:34:18Z Article http://purl.org/eprint/type/ConferencePaper 978-0-7918-4392-5 http://hdl.handle.net/1721.1/117221 Buehler, Markus J., and Jérémie Bertaud. “Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments.” ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (2010). https://orcid.org/0000-0002-4173-9659 http://dx.doi.org/10.1115/NEMB2010-13103 ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf ASME International ASME |
| spellingShingle | Bertaud, Jérémie Buehler, Markus J Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_full | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_fullStr | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_full_unstemmed | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_short | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_sort | hierarchical structure controls nanomechanical properties of vimentin intermediate filaments |
| url | http://hdl.handle.net/1721.1/117221 https://orcid.org/0000-0002-4173-9659 |
| work_keys_str_mv | AT bertaudjeremie hierarchicalstructurecontrolsnanomechanicalpropertiesofvimentinintermediatefilaments AT buehlermarkusj hierarchicalstructurecontrolsnanomechanicalpropertiesofvimentinintermediatefilaments |