Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly linked variants like...
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| Format: | Article |
| Published: |
Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/117265 https://orcid.org/0000-0002-7250-4107 |
| _version_ | 1826196429480132608 |
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| author | Rusu, Victor Hoch, Eitan Mercader, Josep M. Tenen, Danielle E. Gymrek, Melissa Hartigan, Christina R. DeRan, Michael von Grotthuss, Marcin Fontanillas, Pierre Spooner, Alexandra Guzman, Gaelen Deik, Amy A. Pierce, Kerry A. Dennis, Courtney Clish, Clary B. Carr, Steven A. Wagner, Bridget K. Schenone, Monica Ng, Maggie C.Y. Chen, Brian H. Centeno-Cruz, Federico Zerrweck, Carlos Orozco, Lorena Schreiber, Stuart L. Florez, Jose C. Jacobs, Suzanne B.R. Ng, Maggie C.Y. Shriner, Daniel Chen, Brian H. Li, Jiang Chen, Wei-Min Guo, Xiuqing Liu, Jiankang Bielinski, Suzette J. Yanek, Lisa R. Nalls, Michael A. Comeau, Mary E. Rasmussen-Torvik, Laura J. Jensen, Richard A. Evans, Daniel S. Sun, Yan V. An, Ping Patel, Sanjay R. Lu, Yingchang Long, Jirong Armstrong, Loren L. Wagenknecht, Lynne Yang, Lingyao Snively, Beverly M. Palmer, Nicholette D. Mudgal, Poorva Langefeld, Carl D. Keene, Keith L. Freedman, Barry I. Mychaleckyj, Josyf C. Nayak, Uma Raffel, Leslie J. Goodarzi, Mark O. Chen, Y-D Ida Taylor, Herman A. Correa, Adolfo Sims, Mario Couper, David Pankow, James S. Boerwinkle, Eric Adeyemo, Adebowale Doumatey, Ayo Chen, Guanjie Mathias, Rasika A. Vaidya, Dhananjay Singleton, Andrew B. Zonderman, Alan B. Igo, Robert P. Sedor, John R. Kabagambe, Edmond K. Siscovick, David S. McKnight, Barbara Rice, Kenneth Liu, Yongmei Hsueh, Wen-Chi Zhao, Wei Bielak, Lawrence F. Kraja, Aldi Province, Michael A. Bottinger, Erwin P. Gottesman, Omri Cai, Qiuyin Zheng, Wei Blot, William J. Lowe, William L. Pacheco, Jennifer A. Crawford, Dana C. Grundberg, Elin Rich, Stephen S. Hayes, M. Geoffrey Shu, Xiao-Ou Loos, Ruth J.F. Borecki, Ingrid B. Peyser, Patricia A. Cummings, Steven R. Psaty, Bruce M. Fornage, Myriam Iyengar, Sudha K. Evans, Michele K. Becker, Diane M. Kao, W.H. Linda Wilson, James G. Rotter, Jerome I. Sale, Michèle M. Liu, Simin Rotimi, Charles N. Bowden, Donald W. Mercader, Josep M. Huerta-Chagoya, Alicia García-Ortiz, Humberto Moreno-Macías, Hortensia Manning, Alisa Caulkins, Lizz Burtt, Noël P. Flannick, Jason Patterson, Nick Aguilar-Salinas, Carlos A. Tusié-Luna, Teresa Altshuler, David Florez, Jose C. Martínez-Hernández, Angélica Centeno-Cruz, Federico Barajas-Olmos, Francisco Martin Zerrweck, Carlos Contreras-Cubas, Cecilia Mendoza-Caamal, Elvia Revilla-Monsalve, Cristina Islas-Andrade, Sergio Córdova, Emilio Soberón, Xavier Orozco, Lorena González-Villalpando, Clicerio González-Villalpando, María Elena Haiman, Christopher A. Wilkens, Lynne Le Marchand, Loic Monroe, Kristine Kolonel, Laurence Arellano-Campos, Olimpia Ordóñez-Sánchez, Maria L. Rodríguez-Torres, Maribel Segura-Kato, Yayoi Rodríguez-Guillén, Rosario Cruz-Bautista, Ivette Muñoz-Hernandez, Linda Liliana Sáenz, Tamara Gómez, Donají Alvirde, Ulices Almeda-Valdés, Paloma Cortes, Maria L. Lander, Eric Steven Altshuler, David |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Rusu, Victor Hoch, Eitan Mercader, Josep M. Tenen, Danielle E. Gymrek, Melissa Hartigan, Christina R. DeRan, Michael von Grotthuss, Marcin Fontanillas, Pierre Spooner, Alexandra Guzman, Gaelen Deik, Amy A. Pierce, Kerry A. Dennis, Courtney Clish, Clary B. Carr, Steven A. Wagner, Bridget K. Schenone, Monica Ng, Maggie C.Y. Chen, Brian H. Centeno-Cruz, Federico Zerrweck, Carlos Orozco, Lorena Schreiber, Stuart L. Florez, Jose C. Jacobs, Suzanne B.R. Ng, Maggie C.Y. Shriner, Daniel Chen, Brian H. Li, Jiang Chen, Wei-Min Guo, Xiuqing Liu, Jiankang Bielinski, Suzette J. Yanek, Lisa R. Nalls, Michael A. Comeau, Mary E. Rasmussen-Torvik, Laura J. Jensen, Richard A. Evans, Daniel S. Sun, Yan V. An, Ping Patel, Sanjay R. Lu, Yingchang Long, Jirong Armstrong, Loren L. Wagenknecht, Lynne Yang, Lingyao Snively, Beverly M. Palmer, Nicholette D. Mudgal, Poorva Langefeld, Carl D. Keene, Keith L. Freedman, Barry I. Mychaleckyj, Josyf C. Nayak, Uma Raffel, Leslie J. Goodarzi, Mark O. Chen, Y-D Ida Taylor, Herman A. Correa, Adolfo Sims, Mario Couper, David Pankow, James S. Boerwinkle, Eric Adeyemo, Adebowale Doumatey, Ayo Chen, Guanjie Mathias, Rasika A. Vaidya, Dhananjay Singleton, Andrew B. Zonderman, Alan B. Igo, Robert P. Sedor, John R. Kabagambe, Edmond K. Siscovick, David S. McKnight, Barbara Rice, Kenneth Liu, Yongmei Hsueh, Wen-Chi Zhao, Wei Bielak, Lawrence F. Kraja, Aldi Province, Michael A. Bottinger, Erwin P. Gottesman, Omri Cai, Qiuyin Zheng, Wei Blot, William J. Lowe, William L. Pacheco, Jennifer A. Crawford, Dana C. Grundberg, Elin Rich, Stephen S. Hayes, M. Geoffrey Shu, Xiao-Ou Loos, Ruth J.F. Borecki, Ingrid B. Peyser, Patricia A. Cummings, Steven R. Psaty, Bruce M. Fornage, Myriam Iyengar, Sudha K. Evans, Michele K. Becker, Diane M. Kao, W.H. Linda Wilson, James G. Rotter, Jerome I. Sale, Michèle M. Liu, Simin Rotimi, Charles N. Bowden, Donald W. Mercader, Josep M. Huerta-Chagoya, Alicia García-Ortiz, Humberto Moreno-Macías, Hortensia Manning, Alisa Caulkins, Lizz Burtt, Noël P. Flannick, Jason Patterson, Nick Aguilar-Salinas, Carlos A. Tusié-Luna, Teresa Altshuler, David Florez, Jose C. Martínez-Hernández, Angélica Centeno-Cruz, Federico Barajas-Olmos, Francisco Martin Zerrweck, Carlos Contreras-Cubas, Cecilia Mendoza-Caamal, Elvia Revilla-Monsalve, Cristina Islas-Andrade, Sergio Córdova, Emilio Soberón, Xavier Orozco, Lorena González-Villalpando, Clicerio González-Villalpando, María Elena Haiman, Christopher A. Wilkens, Lynne Le Marchand, Loic Monroe, Kristine Kolonel, Laurence Arellano-Campos, Olimpia Ordóñez-Sánchez, Maria L. Rodríguez-Torres, Maribel Segura-Kato, Yayoi Rodríguez-Guillén, Rosario Cruz-Bautista, Ivette Muñoz-Hernandez, Linda Liliana Sáenz, Tamara Gómez, Donají Alvirde, Ulices Almeda-Valdés, Paloma Cortes, Maria L. Lander, Eric Steven Altshuler, David |
| author_sort | Rusu, Victor |
| collection | MIT |
| description | Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly linked variants likely to contain the causal allele(s). We show that variants on the T2D-associated haplotype have two distinct effects: (1) decreasing SLC16A11 expression in liver and (2) disrupting a key interaction with basigin, thereby reducing cell-surface localization. Both independent mechanisms reduce SLC16A11 function and suggest SLC16A11 is the causal gene at this locus. To gain insight into how SLC16A11 disruption impacts T2D risk, we demonstrate that SLC16A11 is a proton-coupled monocarboxylate transporter and that genetic perturbation of SLC16A11 induces changes in fatty acid and lipid metabolism that are associated with increased T2D risk. Our findings suggest that increasing SLC16A11 function could be therapeutically beneficial for T2D. Video Abstract [Figure presented] Keywords: type 2 diabetes (T2D); genetics; disease mechanism; SLC16A11; MCT11; solute carrier (SLC); monocarboxylates; fatty acid metabolism; lipid metabolism; precision medicine |
| first_indexed | 2024-09-23T10:26:44Z |
| format | Article |
| id | mit-1721.1/117265 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:26:44Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1172652022-09-26T17:57:02Z Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms Rusu, Victor Hoch, Eitan Mercader, Josep M. Tenen, Danielle E. Gymrek, Melissa Hartigan, Christina R. DeRan, Michael von Grotthuss, Marcin Fontanillas, Pierre Spooner, Alexandra Guzman, Gaelen Deik, Amy A. Pierce, Kerry A. Dennis, Courtney Clish, Clary B. Carr, Steven A. Wagner, Bridget K. Schenone, Monica Ng, Maggie C.Y. Chen, Brian H. Centeno-Cruz, Federico Zerrweck, Carlos Orozco, Lorena Schreiber, Stuart L. Florez, Jose C. Jacobs, Suzanne B.R. Ng, Maggie C.Y. Shriner, Daniel Chen, Brian H. Li, Jiang Chen, Wei-Min Guo, Xiuqing Liu, Jiankang Bielinski, Suzette J. Yanek, Lisa R. Nalls, Michael A. Comeau, Mary E. Rasmussen-Torvik, Laura J. Jensen, Richard A. Evans, Daniel S. Sun, Yan V. An, Ping Patel, Sanjay R. Lu, Yingchang Long, Jirong Armstrong, Loren L. Wagenknecht, Lynne Yang, Lingyao Snively, Beverly M. Palmer, Nicholette D. Mudgal, Poorva Langefeld, Carl D. Keene, Keith L. Freedman, Barry I. Mychaleckyj, Josyf C. Nayak, Uma Raffel, Leslie J. Goodarzi, Mark O. Chen, Y-D Ida Taylor, Herman A. Correa, Adolfo Sims, Mario Couper, David Pankow, James S. Boerwinkle, Eric Adeyemo, Adebowale Doumatey, Ayo Chen, Guanjie Mathias, Rasika A. Vaidya, Dhananjay Singleton, Andrew B. Zonderman, Alan B. Igo, Robert P. Sedor, John R. Kabagambe, Edmond K. Siscovick, David S. McKnight, Barbara Rice, Kenneth Liu, Yongmei Hsueh, Wen-Chi Zhao, Wei Bielak, Lawrence F. Kraja, Aldi Province, Michael A. Bottinger, Erwin P. Gottesman, Omri Cai, Qiuyin Zheng, Wei Blot, William J. Lowe, William L. Pacheco, Jennifer A. Crawford, Dana C. Grundberg, Elin Rich, Stephen S. Hayes, M. Geoffrey Shu, Xiao-Ou Loos, Ruth J.F. Borecki, Ingrid B. Peyser, Patricia A. Cummings, Steven R. Psaty, Bruce M. Fornage, Myriam Iyengar, Sudha K. Evans, Michele K. Becker, Diane M. Kao, W.H. Linda Wilson, James G. Rotter, Jerome I. Sale, Michèle M. Liu, Simin Rotimi, Charles N. Bowden, Donald W. Mercader, Josep M. Huerta-Chagoya, Alicia García-Ortiz, Humberto Moreno-Macías, Hortensia Manning, Alisa Caulkins, Lizz Burtt, Noël P. Flannick, Jason Patterson, Nick Aguilar-Salinas, Carlos A. Tusié-Luna, Teresa Altshuler, David Florez, Jose C. Martínez-Hernández, Angélica Centeno-Cruz, Federico Barajas-Olmos, Francisco Martin Zerrweck, Carlos Contreras-Cubas, Cecilia Mendoza-Caamal, Elvia Revilla-Monsalve, Cristina Islas-Andrade, Sergio Córdova, Emilio Soberón, Xavier Orozco, Lorena González-Villalpando, Clicerio González-Villalpando, María Elena Haiman, Christopher A. Wilkens, Lynne Le Marchand, Loic Monroe, Kristine Kolonel, Laurence Arellano-Campos, Olimpia Ordóñez-Sánchez, Maria L. Rodríguez-Torres, Maribel Segura-Kato, Yayoi Rodríguez-Guillén, Rosario Cruz-Bautista, Ivette Muñoz-Hernandez, Linda Liliana Sáenz, Tamara Gómez, Donají Alvirde, Ulices Almeda-Valdés, Paloma Cortes, Maria L. Lander, Eric Steven Altshuler, David Massachusetts Institute of Technology. Department of Biology Altshuler, David M Lander, Eric Steven Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly linked variants likely to contain the causal allele(s). We show that variants on the T2D-associated haplotype have two distinct effects: (1) decreasing SLC16A11 expression in liver and (2) disrupting a key interaction with basigin, thereby reducing cell-surface localization. Both independent mechanisms reduce SLC16A11 function and suggest SLC16A11 is the causal gene at this locus. To gain insight into how SLC16A11 disruption impacts T2D risk, we demonstrate that SLC16A11 is a proton-coupled monocarboxylate transporter and that genetic perturbation of SLC16A11 induces changes in fatty acid and lipid metabolism that are associated with increased T2D risk. Our findings suggest that increasing SLC16A11 function could be therapeutically beneficial for T2D. Video Abstract [Figure presented] Keywords: type 2 diabetes (T2D); genetics; disease mechanism; SLC16A11; MCT11; solute carrier (SLC); monocarboxylates; fatty acid metabolism; lipid metabolism; precision medicine 2018-08-01T17:24:05Z 2018-08-01T17:24:05Z 2017-06 2017-03 2018-08-01T15:12:54Z Article http://purl.org/eprint/type/JournalArticle 0962-8924 http://hdl.handle.net/1721.1/117265 Rusu, Victor et al. “Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.” Cell 170, 1 (June 2017): 199–212 © 2017 Elsevier Inc https://orcid.org/0000-0002-7250-4107 http://dx.doi.org/10.1016/J.CELL.2017.06.011 Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Rusu, Victor Hoch, Eitan Mercader, Josep M. Tenen, Danielle E. Gymrek, Melissa Hartigan, Christina R. DeRan, Michael von Grotthuss, Marcin Fontanillas, Pierre Spooner, Alexandra Guzman, Gaelen Deik, Amy A. Pierce, Kerry A. Dennis, Courtney Clish, Clary B. Carr, Steven A. Wagner, Bridget K. Schenone, Monica Ng, Maggie C.Y. Chen, Brian H. Centeno-Cruz, Federico Zerrweck, Carlos Orozco, Lorena Schreiber, Stuart L. Florez, Jose C. Jacobs, Suzanne B.R. Ng, Maggie C.Y. Shriner, Daniel Chen, Brian H. Li, Jiang Chen, Wei-Min Guo, Xiuqing Liu, Jiankang Bielinski, Suzette J. Yanek, Lisa R. Nalls, Michael A. Comeau, Mary E. Rasmussen-Torvik, Laura J. Jensen, Richard A. Evans, Daniel S. Sun, Yan V. An, Ping Patel, Sanjay R. Lu, Yingchang Long, Jirong Armstrong, Loren L. Wagenknecht, Lynne Yang, Lingyao Snively, Beverly M. Palmer, Nicholette D. Mudgal, Poorva Langefeld, Carl D. Keene, Keith L. Freedman, Barry I. Mychaleckyj, Josyf C. Nayak, Uma Raffel, Leslie J. Goodarzi, Mark O. Chen, Y-D Ida Taylor, Herman A. Correa, Adolfo Sims, Mario Couper, David Pankow, James S. Boerwinkle, Eric Adeyemo, Adebowale Doumatey, Ayo Chen, Guanjie Mathias, Rasika A. Vaidya, Dhananjay Singleton, Andrew B. Zonderman, Alan B. Igo, Robert P. Sedor, John R. Kabagambe, Edmond K. Siscovick, David S. McKnight, Barbara Rice, Kenneth Liu, Yongmei Hsueh, Wen-Chi Zhao, Wei Bielak, Lawrence F. Kraja, Aldi Province, Michael A. Bottinger, Erwin P. Gottesman, Omri Cai, Qiuyin Zheng, Wei Blot, William J. Lowe, William L. Pacheco, Jennifer A. Crawford, Dana C. Grundberg, Elin Rich, Stephen S. Hayes, M. Geoffrey Shu, Xiao-Ou Loos, Ruth J.F. Borecki, Ingrid B. Peyser, Patricia A. Cummings, Steven R. Psaty, Bruce M. Fornage, Myriam Iyengar, Sudha K. Evans, Michele K. Becker, Diane M. Kao, W.H. Linda Wilson, James G. Rotter, Jerome I. Sale, Michèle M. Liu, Simin Rotimi, Charles N. Bowden, Donald W. Mercader, Josep M. Huerta-Chagoya, Alicia García-Ortiz, Humberto Moreno-Macías, Hortensia Manning, Alisa Caulkins, Lizz Burtt, Noël P. Flannick, Jason Patterson, Nick Aguilar-Salinas, Carlos A. Tusié-Luna, Teresa Altshuler, David Florez, Jose C. Martínez-Hernández, Angélica Centeno-Cruz, Federico Barajas-Olmos, Francisco Martin Zerrweck, Carlos Contreras-Cubas, Cecilia Mendoza-Caamal, Elvia Revilla-Monsalve, Cristina Islas-Andrade, Sergio Córdova, Emilio Soberón, Xavier Orozco, Lorena González-Villalpando, Clicerio González-Villalpando, María Elena Haiman, Christopher A. Wilkens, Lynne Le Marchand, Loic Monroe, Kristine Kolonel, Laurence Arellano-Campos, Olimpia Ordóñez-Sánchez, Maria L. Rodríguez-Torres, Maribel Segura-Kato, Yayoi Rodríguez-Guillén, Rosario Cruz-Bautista, Ivette Muñoz-Hernandez, Linda Liliana Sáenz, Tamara Gómez, Donají Alvirde, Ulices Almeda-Valdés, Paloma Cortes, Maria L. Lander, Eric Steven Altshuler, David Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms |
| title | Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms |
| title_full | Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms |
| title_fullStr | Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms |
| title_full_unstemmed | Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms |
| title_short | Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms |
| title_sort | type 2 diabetes variants disrupt function of slc16a11 through two distinct mechanisms |
| url | http://hdl.handle.net/1721.1/117265 https://orcid.org/0000-0002-7250-4107 |
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siscovickdavids type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT mcknightbarbara type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT ricekenneth type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT liuyongmei type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT hsuehwenchi type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT zhaowei type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT bielaklawrencef type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT krajaaldi type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT provincemichaela type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT bottingererwinp type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT gottesmanomri type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT caiqiuyin type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT zhengwei type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT blotwilliamj type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT lowewilliaml type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT pachecojennifera type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT crawforddanac type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT grundbergelin type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT richstephens type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT hayesmgeoffrey type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT shuxiaoou type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT loosruthjf type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT boreckiingridb type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT peyserpatriciaa type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT cummingsstevenr type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT psatybrucem type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT fornagemyriam type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT iyengarsudhak type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT evansmichelek type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT beckerdianem type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT kaowhlinda type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT wilsonjamesg type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT rotterjeromei type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT salemichelem type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT liusimin type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT rotimicharlesn type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT bowdendonaldw type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT mercaderjosepm type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT huertachagoyaalicia type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT garciaortizhumberto type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT morenomaciashortensia type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT manningalisa type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT caulkinslizz type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT burttnoelp type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT flannickjason type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT pattersonnick type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT aguilarsalinascarlosa type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT tusielunateresa type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT altshulerdavid type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT florezjosec type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT martinezhernandezangelica type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT centenocruzfederico type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT barajasolmosfranciscomartin type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT zerrweckcarlos type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT contrerascubascecilia type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT mendozacaamalelvia type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT revillamonsalvecristina type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT islasandradesergio type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT cordovaemilio type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT soberonxavier type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT orozcolorena type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT gonzalezvillalpandoclicerio type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT gonzalezvillalpandomariaelena type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT haimanchristophera type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT wilkenslynne type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT lemarchandloic type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT monroekristine type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT kolonellaurence type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT arellanocamposolimpia type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT ordonezsanchezmarial type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT rodrigueztorresmaribel type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT segurakatoyayoi type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT rodriguezguillenrosario type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT cruzbautistaivette type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT munozhernandezlindaliliana type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT saenztamara type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT gomezdonaji type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT alvirdeulices type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT almedavaldespaloma type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT cortesmarial type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT landerericsteven type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms AT altshulerdavid type2diabetesvariantsdisruptfunctionofslc16a11throughtwodistinctmechanisms |