Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments
Intermediate filaments (IFs), in addition to microtubules and microfilaments, are one of the three major components of the cytoskeleton in eukaryotic cells, playing a vital role in mechanotransduction and in providing mechanical stability to cells (Figure 1) [1]. Despite the importance of IF mechani...
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| Format: | Article |
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ASME International
2018
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| Online Access: | http://hdl.handle.net/1721.1/117291 https://orcid.org/0000-0002-4173-9659 |
| _version_ | 1826211293911056384 |
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| author | Buehler, Markus J Qin, Zhao |
| author2 | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Buehler, Markus J Qin, Zhao |
| author_sort | Buehler, Markus J |
| collection | MIT |
| description | Intermediate filaments (IFs), in addition to microtubules and microfilaments, are one of the three major components of the cytoskeleton in eukaryotic cells, playing a vital role in mechanotransduction and in providing mechanical stability to cells (Figure 1) [1]. Despite the importance of IF mechanics for cell biology and cell mechanics, the structural basis for their mechanical properties remains unknown. Specifically, our understanding of fundamental filament properties, such as the basis for their great extensibility, stiffening properties, and their exceptional mechanical resilience remains limited. This has prevented us from answering fundamental structure-function relationship questions related to the biomechanical role of intermediate filaments, which is crucial to link structure and function in the protein material’s biological context. |
| first_indexed | 2024-09-23T15:03:57Z |
| format | Article |
| id | mit-1721.1/117291 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T15:03:57Z |
| publishDate | 2018 |
| publisher | ASME International |
| record_format | dspace |
| spelling | mit-1721.1/1172912022-10-02T00:21:23Z Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments Buehler, Markus J Qin, Zhao Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Buehler, Markus J Qin, Zhao Intermediate filaments (IFs), in addition to microtubules and microfilaments, are one of the three major components of the cytoskeleton in eukaryotic cells, playing a vital role in mechanotransduction and in providing mechanical stability to cells (Figure 1) [1]. Despite the importance of IF mechanics for cell biology and cell mechanics, the structural basis for their mechanical properties remains unknown. Specifically, our understanding of fundamental filament properties, such as the basis for their great extensibility, stiffening properties, and their exceptional mechanical resilience remains limited. This has prevented us from answering fundamental structure-function relationship questions related to the biomechanical role of intermediate filaments, which is crucial to link structure and function in the protein material’s biological context. 2018-08-07T12:21:02Z 2018-08-07T12:21:02Z 2010-02 2018-07-27T17:32:01Z Article http://purl.org/eprint/type/ConferencePaper 978-0-7918-4392-5 http://hdl.handle.net/1721.1/117291 Buehler, Markus J., and Zhao Qin. “Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments.” ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (2010). https://orcid.org/0000-0002-4173-9659 http://dx.doi.org/10.1115/NEMB2010-13102 ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf ASME International ASME |
| spellingShingle | Buehler, Markus J Qin, Zhao Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_full | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_fullStr | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_full_unstemmed | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_short | Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments |
| title_sort | hierarchical structure controls nanomechanical properties of vimentin intermediate filaments |
| url | http://hdl.handle.net/1721.1/117291 https://orcid.org/0000-0002-4173-9659 |
| work_keys_str_mv | AT buehlermarkusj hierarchicalstructurecontrolsnanomechanicalpropertiesofvimentinintermediatefilaments AT qinzhao hierarchicalstructurecontrolsnanomechanicalpropertiesofvimentinintermediatefilaments |