Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma

Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma

De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans, requires sequential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epimerase-4-reductase (FX or tissue specific transplantation antigen P35B [TSTA3]). GMDS deletions a...

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Bibliographic Details
Main Authors: Wang, Yiwei, Huang, Dan, Chen, Kai-Yuan, Cui, Min, Wang, Weihuan, Huang, Xiaoran, Awadellah, Amad, Li, Qing, Friedman, Ann, Xin, William W., Di Martino, Luca, Cominelli, Fabio, Miron, Alex, Chan, Ricky, Fox, James G., Xu, Yan, Shen, Xiling, Kalady, Mathew F., Markowitz, Sanford, Maillard, Ivan, Lowe, John B., Xin, Wei, Zhou, Lan, Fox, James G
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/117652
https://orcid.org/0000-0001-9307-6116

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