Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer
Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B₁ in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Informa UK Limited
2018
|
| Online Access: | http://hdl.handle.net/1721.1/117661 https://orcid.org/0000-0001-5252-826X https://orcid.org/0000-0003-0176-1920 https://orcid.org/0000-0003-0771-9889 https://orcid.org/0000-0002-2196-5691 |
| _version_ | 1826217200890937344 |
|---|---|
| author | Fedeles, Bogdan I Chawanthayatham, Supawadee Croy, Robert G Wogan, Gerald N Essigmann, John M |
| author2 | Massachusetts Institute of Technology. Center for Environmental Health Sciences |
| author_facet | Massachusetts Institute of Technology. Center for Environmental Health Sciences Fedeles, Bogdan I Chawanthayatham, Supawadee Croy, Robert G Wogan, Gerald N Essigmann, John M |
| author_sort | Fedeles, Bogdan I |
| collection | MIT |
| description | Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B₁ in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by accurately identifying, among the sequenced human liver tumors, the subset of cancers associated with aflatoxin B₁ exposure. Keywords: Duplex sequencing; HCC; hepatocellular carcinoma; mutagenesis; mutational signature; mycotoxins |
| first_indexed | 2024-09-23T16:59:38Z |
| format | Article |
| id | mit-1721.1/117661 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:59:38Z |
| publishDate | 2018 |
| publisher | Informa UK Limited |
| record_format | dspace |
| spelling | mit-1721.1/1176612022-10-03T09:41:12Z Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer Fedeles, Bogdan I Chawanthayatham, Supawadee Croy, Robert G Wogan, Gerald N Essigmann, John M Massachusetts Institute of Technology. Center for Environmental Health Sciences Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemistry Fedeles, Bogdan I Chawanthayatham, Supawadee Croy, Robert G Wogan, Gerald N Essigmann, John M Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B₁ in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by accurately identifying, among the sequenced human liver tumors, the subset of cancers associated with aflatoxin B₁ exposure. Keywords: Duplex sequencing; HCC; hepatocellular carcinoma; mutagenesis; mutational signature; mycotoxins 2018-09-07T13:14:04Z 2018-09-07T13:14:04Z 2017-07 2017-05 2018-08-28T18:23:37Z Article http://purl.org/eprint/type/JournalArticle 2372-3556 http://hdl.handle.net/1721.1/117661 Fedeles, Bogdan I. et al. “Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer.” Molecular & Cellular Oncology 4, 4 (May 2017): e1329693 © 2017 The Author(s) https://orcid.org/0000-0001-5252-826X https://orcid.org/0000-0003-0176-1920 https://orcid.org/0000-0003-0771-9889 https://orcid.org/0000-0002-2196-5691 http://dx.doi.org/10.1080/23723556.2017.1329693 Molecular & Cellular Oncology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Informa UK Limited Taylor & Francis |
| spellingShingle | Fedeles, Bogdan I Chawanthayatham, Supawadee Croy, Robert G Wogan, Gerald N Essigmann, John M Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer |
| title | Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer |
| title_full | Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer |
| title_fullStr | Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer |
| title_full_unstemmed | Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer |
| title_short | Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer |
| title_sort | early detection of the aflatoxin b₁ mutational fingerprint a diagnostic tool for liver cancer |
| url | http://hdl.handle.net/1721.1/117661 https://orcid.org/0000-0001-5252-826X https://orcid.org/0000-0003-0176-1920 https://orcid.org/0000-0003-0771-9889 https://orcid.org/0000-0002-2196-5691 |
| work_keys_str_mv | AT fedelesbogdani earlydetectionoftheaflatoxinb1mutationalfingerprintadiagnostictoolforlivercancer AT chawanthayathamsupawadee earlydetectionoftheaflatoxinb1mutationalfingerprintadiagnostictoolforlivercancer AT croyrobertg earlydetectionoftheaflatoxinb1mutationalfingerprintadiagnostictoolforlivercancer AT wogangeraldn earlydetectionoftheaflatoxinb1mutationalfingerprintadiagnostictoolforlivercancer AT essigmannjohnm earlydetectionoftheaflatoxinb1mutationalfingerprintadiagnostictoolforlivercancer |