The particle in the spider's web: transport through biological hydrogels
Biological hydrogels such as mucus, extracellular matrix, biofilms, and the nuclear pore have diverse functions and compositions, but all act as selectively permeable barriers to the diffusion of particles. Each barrier has a crosslinked polymeric mesh that blocks penetration of large particles such...
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| Format: | Article |
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Royal Society of Chemistry (RSC)
2018
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| Online Access: | http://hdl.handle.net/1721.1/117712 https://orcid.org/0000-0003-0037-5999 https://orcid.org/0000-0001-8260-338X |
| _version_ | 1811096042538532864 |
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| author | Witten, Jacob Ribbeck, Katharina Witten, Jacob Julian Seid |
| author2 | Massachusetts Institute of Technology. Computational and Systems Biology Program |
| author_facet | Massachusetts Institute of Technology. Computational and Systems Biology Program Witten, Jacob Ribbeck, Katharina Witten, Jacob Julian Seid |
| author_sort | Witten, Jacob |
| collection | MIT |
| description | Biological hydrogels such as mucus, extracellular matrix, biofilms, and the nuclear pore have diverse functions and compositions, but all act as selectively permeable barriers to the diffusion of particles. Each barrier has a crosslinked polymeric mesh that blocks penetration of large particles such as pathogens, nanotherapeutics, or macromolecules. These polymeric meshes also employ interactive filtering, in which affinity between solutes and the gel matrix controls permeability. Interactive filtering affects the transport of particles of all sizes including peptides, antibiotics, and nanoparticles and in many cases this filtering can be described in terms of the effects of charge and hydrophobicity. The concepts described in this review can guide strategies to exploit or overcome gel barriers, particularly for applications in diagnostics, pharmacology, biomaterials, and drug delivery. |
| first_indexed | 2024-09-23T16:37:25Z |
| format | Article |
| id | mit-1721.1/117712 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:37:25Z |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry (RSC) |
| record_format | dspace |
| spelling | mit-1721.1/1177122022-09-29T20:25:54Z The particle in the spider's web: transport through biological hydrogels Witten, Jacob Ribbeck, Katharina Witten, Jacob Julian Seid Massachusetts Institute of Technology. Computational and Systems Biology Program Massachusetts Institute of Technology. Department of Biological Engineering Witten, Jacob Julian Seid Ribbeck, Katharina Biological hydrogels such as mucus, extracellular matrix, biofilms, and the nuclear pore have diverse functions and compositions, but all act as selectively permeable barriers to the diffusion of particles. Each barrier has a crosslinked polymeric mesh that blocks penetration of large particles such as pathogens, nanotherapeutics, or macromolecules. These polymeric meshes also employ interactive filtering, in which affinity between solutes and the gel matrix controls permeability. Interactive filtering affects the transport of particles of all sizes including peptides, antibiotics, and nanoparticles and in many cases this filtering can be described in terms of the effects of charge and hydrophobicity. The concepts described in this review can guide strategies to exploit or overcome gel barriers, particularly for applications in diagnostics, pharmacology, biomaterials, and drug delivery. National Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (DMR – 0819762) National Science Foundation (U.S.) (NSF R01 R01-EB017755) National Science Foundation (U.S.) (NSF Career PHY-1454673) National Science Foundation (U.S.). Graduate Research Fellowship Program (Grant 1122374) 2018-09-11T15:38:44Z 2018-09-11T15:38:44Z 2017-05 2016-12 2018-09-10T17:00:57Z Article http://purl.org/eprint/type/JournalArticle 2040-3364 2040-3372 http://hdl.handle.net/1721.1/117712 Witten, Jacob, and Katharina Ribbeck. “The Particle in the Spider’s Web: Transport through Biological Hydrogels.” Nanoscale, vol. 9, no. 24, 2017, pp. 8080–95. © 2017 The Royal Society of Chemistry. https://orcid.org/0000-0003-0037-5999 https://orcid.org/0000-0001-8260-338X http://dx.doi.org/10.1039/C6NR09736G Nanoscale Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Royal Society of Chemistry (RSC) PMC |
| spellingShingle | Witten, Jacob Ribbeck, Katharina Witten, Jacob Julian Seid The particle in the spider's web: transport through biological hydrogels |
| title | The particle in the spider's web: transport through biological hydrogels |
| title_full | The particle in the spider's web: transport through biological hydrogels |
| title_fullStr | The particle in the spider's web: transport through biological hydrogels |
| title_full_unstemmed | The particle in the spider's web: transport through biological hydrogels |
| title_short | The particle in the spider's web: transport through biological hydrogels |
| title_sort | particle in the spider s web transport through biological hydrogels |
| url | http://hdl.handle.net/1721.1/117712 https://orcid.org/0000-0003-0037-5999 https://orcid.org/0000-0001-8260-338X |
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