Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases

Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases

The gut microbiota modulate host biology in numerous ways, but little is known about the molecular mediators of these interactions. Previously, we found a widely distributed family of nonribosomal peptide synthetase gene clusters in gut bacteria. Here, by expressing a subset of these clusters in Esc...

Full description

Bibliographic Details
Main Authors: Guo, Chun-Jun, Chang, Fang-Yuan, Wyche, Thomas P., Backus, Keriann M., Acker, Timothy M., Funabashi, Masanori, Taketani, Mao, Donia, Mohamed S., Nayfach, Stephen, Pollard, Katherine S., Craik, Charles S., Cravatt, Benjamin F., Clardy, Jon, Voigt, Christopher A., Fischbach, Michael A.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/117726
https://orcid.org/0000-0002-3783-0433
https://orcid.org/0000-0003-0844-4776

Similar Items

Similar Items