Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis

Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis

Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic interactions were uti...

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Bibliographic Details
Main Authors: De la Vega, RE, Scheu, M, Brown, LA, Fitzsimons, TJ, Porter, RM, Bajpayee, Ambika Goel, Varady, Nathan H., Yannatos, I. A., Krishnan, Yamini, Bhattacharya, Paulomi, Frank, Eliot Henry, Grodzinsky, Alan J, Porter, R. M.
Other Authors: Massachusetts Institute of Technology. Center for Biomedical Engineering
Format: Article
Published: ECM Research Journal 2018
Online Access:http://hdl.handle.net/1721.1/117741
https://orcid.org/0000-0003-4750-7207
https://orcid.org/0000-0001-7880-1391
https://orcid.org/0000-0002-4942-3456

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