The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex
A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectru...
| Những tác giả chính: | , , , , , |
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| Tác giả khác: | |
| Định dạng: | Bài viết |
| Được phát hành: |
Royal Society of Chemistry (RSC)
2018
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| Truy cập trực tuyến: | http://hdl.handle.net/1721.1/117762 https://orcid.org/0000-0002-5503-2371 https://orcid.org/0000-0002-6801-0198 https://orcid.org/0000-0002-7577-4612 https://orcid.org/0000-0002-2693-4982 |
| Tóm tắt: | A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin. |
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