Smart Radiation Therapy Biomaterials
Radiation therapy (RT) is a crucial component of cancer care, used in the treatment of over 50% of cancer patients. Patients undergoing image guided RT or brachytherapy routinely have inert RT biomaterials implanted into their tumors. The single function of these RT biomaterials is to ensure geometr...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Elsevier BV
2018
|
| Online Access: | http://hdl.handle.net/1721.1/117771 |
| _version_ | 1811069471660441600 |
|---|---|
| author | Ngwa, Wilfred Boateng, Francis Kumar, Rajiv Formenti, Silvia Ngoma, Twalib Herskind, Carsten Veldwijk, Marlon R. Hildenbrand, Georg Lars Wenz, Frederik Hesser, Juergen Irvine, Darrell J Hausmann, Michael Karlheinz |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Ngwa, Wilfred Boateng, Francis Kumar, Rajiv Formenti, Silvia Ngoma, Twalib Herskind, Carsten Veldwijk, Marlon R. Hildenbrand, Georg Lars Wenz, Frederik Hesser, Juergen Irvine, Darrell J Hausmann, Michael Karlheinz |
| author_sort | Ngwa, Wilfred |
| collection | MIT |
| description | Radiation therapy (RT) is a crucial component of cancer care, used in the treatment of over 50% of cancer patients. Patients undergoing image guided RT or brachytherapy routinely have inert RT biomaterials implanted into their tumors. The single function of these RT biomaterials is to ensure geometric accuracy during treatment. Recent studies have proposed that the inert biomaterials could be upgraded to “smart” RT biomaterials, designed to do more than 1 function. Such smart biomaterials include next-generation fiducial markers, brachytherapy spacers, and balloon applicators, designed to respond to stimuli and perform additional desirable functions like controlled delivery of therapy-enhancing payloads directly into the tumor subvolume while minimizing normal tissue toxicities. More broadly, smart RT biomaterials may include functionalized nanoparticles that can be activated to boost RT efficacy. This work reviews the rationale for smart RT biomaterials, the state of the art in this emerging cross-disciplinary research area, challenges and opportunities for further research and development, and a purview of potential clinical applications. Applications covered include using smart RT biomaterials for boosting cancer therapy with minimal side effects, combining RT with immunotherapy or chemotherapy, reducing treatment time or health care costs, and other incipient applications. |
| first_indexed | 2024-09-23T08:10:58Z |
| format | Article |
| id | mit-1721.1/117771 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:10:58Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1177712024-03-20T19:49:40Z Smart Radiation Therapy Biomaterials Ngwa, Wilfred Boateng, Francis Kumar, Rajiv Formenti, Silvia Ngoma, Twalib Herskind, Carsten Veldwijk, Marlon R. Hildenbrand, Georg Lars Wenz, Frederik Hesser, Juergen Irvine, Darrell J Hausmann, Michael Karlheinz Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Irvine, Darrell J Hausmann, Michael Karlheinz Radiation therapy (RT) is a crucial component of cancer care, used in the treatment of over 50% of cancer patients. Patients undergoing image guided RT or brachytherapy routinely have inert RT biomaterials implanted into their tumors. The single function of these RT biomaterials is to ensure geometric accuracy during treatment. Recent studies have proposed that the inert biomaterials could be upgraded to “smart” RT biomaterials, designed to do more than 1 function. Such smart biomaterials include next-generation fiducial markers, brachytherapy spacers, and balloon applicators, designed to respond to stimuli and perform additional desirable functions like controlled delivery of therapy-enhancing payloads directly into the tumor subvolume while minimizing normal tissue toxicities. More broadly, smart RT biomaterials may include functionalized nanoparticles that can be activated to boost RT efficacy. This work reviews the rationale for smart RT biomaterials, the state of the art in this emerging cross-disciplinary research area, challenges and opportunities for further research and development, and a purview of potential clinical applications. Applications covered include using smart RT biomaterials for boosting cancer therapy with minimal side effects, combining RT with immunotherapy or chemotherapy, reducing treatment time or health care costs, and other incipient applications. 2018-09-17T12:58:23Z 2018-09-17T12:58:23Z 2017-03 2018-09-06T18:07:04Z Article http://purl.org/eprint/type/JournalArticle 03603016 http://hdl.handle.net/1721.1/117771 Ngwa, Wilfred, Francis Boateng, Rajiv Kumar, Darrell J. Irvine, Silvia Formenti, Twalib Ngoma, Carsten Herskind, et al. “Smart Radiation Therapy Biomaterials.” International Journal of Radiation Oncology*Biology*Physics 97, no. 3 (March 2017): 624–637. http://dx.doi.org/10.1016/J.IJROBP.2016.10.034 International Journal of Radiation Oncology*Biology*Physics Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Ngwa, Wilfred Boateng, Francis Kumar, Rajiv Formenti, Silvia Ngoma, Twalib Herskind, Carsten Veldwijk, Marlon R. Hildenbrand, Georg Lars Wenz, Frederik Hesser, Juergen Irvine, Darrell J Hausmann, Michael Karlheinz Smart Radiation Therapy Biomaterials |
| title | Smart Radiation Therapy Biomaterials |
| title_full | Smart Radiation Therapy Biomaterials |
| title_fullStr | Smart Radiation Therapy Biomaterials |
| title_full_unstemmed | Smart Radiation Therapy Biomaterials |
| title_short | Smart Radiation Therapy Biomaterials |
| title_sort | smart radiation therapy biomaterials |
| url | http://hdl.handle.net/1721.1/117771 |
| work_keys_str_mv | AT ngwawilfred smartradiationtherapybiomaterials AT boatengfrancis smartradiationtherapybiomaterials AT kumarrajiv smartradiationtherapybiomaterials AT formentisilvia smartradiationtherapybiomaterials AT ngomatwalib smartradiationtherapybiomaterials AT herskindcarsten smartradiationtherapybiomaterials AT veldwijkmarlonr smartradiationtherapybiomaterials AT hildenbrandgeorglars smartradiationtherapybiomaterials AT wenzfrederik smartradiationtherapybiomaterials AT hesserjuergen smartradiationtherapybiomaterials AT irvinedarrellj smartradiationtherapybiomaterials AT hausmannmichaelkarlheinz smartradiationtherapybiomaterials |