Amygdala circuits underlying valence-specific behaviors
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018.
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| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2018
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| Online Access: | http://hdl.handle.net/1721.1/117881 |
| _version_ | 1811073460448788480 |
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| author | Kim, Joshua |
| author2 | Susumu Tonegawa. |
| author_facet | Susumu Tonegawa. Kim, Joshua |
| author_sort | Kim, Joshua |
| collection | MIT |
| description | Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018. |
| first_indexed | 2024-09-23T09:33:28Z |
| format | Thesis |
| id | mit-1721.1/117881 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T09:33:28Z |
| publishDate | 2018 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1178812022-07-09T04:40:15Z Amygdala circuits underlying valence-specific behaviors Kim, Joshua Susumu Tonegawa. Massachusetts Institute of Technology. Department of Biology. Massachusetts Institute of Technology. Department of Biology Biology. Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018. Cataloged from PDF version of thesis. Includes bibliographical references (pages 54-61). Threatening and rewarding stimuli evoke a set of distinct stereotyped behaviors, which can be categorized as negative and positive valence-related behaviors, respectively. The stereotypic nature of negative and positive valence-related behaviors suggests that threatening and rewarding stimuli engage evolutionarily predetermined neural circuits in the brain. The amygdala is an important mammalian brain region that is activated by negative and positive stimuli and mediates negative and positive valence-related behaviors. The current prevailing circuit model of the amygdala mainly considers negative behaviors and only recently has cell-type specific models have been proposed. Hence, the substrates, genetically distinct neuronal populations, for negative and positive behaviors are not known. The work presented here describes a genetically-defined amygdala circuit model for negative and positive behaviors. Development of a genetic-based circuit model of the amygdala revealed anatomical and genetic circuit motifs that underlie that amygdala circuits that mediate valence-specific behaviors. NIH Pre-Doctoral Training Grant T32GM007287 RIKEN Brain Science Institute by Joshua Kim. Ph. D. 2018-09-17T15:48:22Z 2018-09-17T15:48:22Z 2018 2018 Thesis http://hdl.handle.net/1721.1/117881 1051190565 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 134 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biology. Kim, Joshua Amygdala circuits underlying valence-specific behaviors |
| title | Amygdala circuits underlying valence-specific behaviors |
| title_full | Amygdala circuits underlying valence-specific behaviors |
| title_fullStr | Amygdala circuits underlying valence-specific behaviors |
| title_full_unstemmed | Amygdala circuits underlying valence-specific behaviors |
| title_short | Amygdala circuits underlying valence-specific behaviors |
| title_sort | amygdala circuits underlying valence specific behaviors |
| topic | Biology. |
| url | http://hdl.handle.net/1721.1/117881 |
| work_keys_str_mv | AT kimjoshua amygdalacircuitsunderlyingvalencespecificbehaviors |