Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2018
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| Online Access: | http://hdl.handle.net/1721.1/118085 |
| _version_ | 1826200604098166784 |
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| author | Liang, Kaicheng |
| author2 | James G. Fujimoto. |
| author_facet | James G. Fujimoto. Liang, Kaicheng |
| author_sort | Liang, Kaicheng |
| collection | MIT |
| description | Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018. |
| first_indexed | 2024-09-23T11:39:01Z |
| format | Thesis |
| id | mit-1721.1/118085 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:39:01Z |
| publishDate | 2018 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1180852019-04-10T16:26:40Z Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging Liang, Kaicheng James G. Fujimoto. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018. Cataloged from PDF version of thesis. Includes bibliographical references (pages 139-149). Diseases of the gastrointestinal (GI) tract are typically diagnosed by random biopsy of tissue, which samples only a small area and often misses focal neoplasias. Existing endoscopic visualization tools including white light endoscopy, narrowband imaging and confocal laser endomicroscopy have enabled in vivo assessment to guide biopsies, but suffer from technical limitations and have demonstrated suboptimal sensitivity and specificity to neoplasia. Optical Coherence Tomography (OCT) can generate in vivo, 3-dimensional microscopic imaging. Recent efforts in ultrahigh-speed OCT systems for endoscopic applications have shown promise, but devices had limited fields of view and imprecise beam scanning mechanisms, limiting image quality and coverage. This thesis develops a wide range of new fiber optic devices that substantially extend OCT capabilities in the GI tract, either by greatly increasing field of view for wide field mapping of entire luminal organs, or achieving high precision 2-D beam scanning with compact actuators for in vivo microscopy. Piezoelectrically actuated fiber scanning devices enable forward viewing for focal inspection, while micromotor actuators combined with pneumatic or piezoelectric mechanisms enclosed in tethered capsules generate side viewing over large areas. The work also advances the emerging paradigm of gastrointestinal screening without use of sedation, which promises to lower costs of screening and improve access for a broader population. Design, fabrication and benchtop evaluation of devices, as well as pre-clinical and clinical imaging protocols are reported. Results from validation studies in living swine, and human patients in collaboration with the Veterans Affairs Boston Healthcare System are discussed. The thesis work demonstrates new imaging modalities for in vivo detection and diagnosis of GI pathology that could have important applications in disease screening, surveillance, and therapeutic procedures. by Kaicheng Liang. Ph. D. 2018-09-17T15:56:51Z 2018-09-17T15:56:51Z 2018 2018 Thesis http://hdl.handle.net/1721.1/118085 1052123984 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 149 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Liang, Kaicheng Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging |
| title | Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging |
| title_full | Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging |
| title_fullStr | Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging |
| title_full_unstemmed | Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging |
| title_short | Development and investigation of devices for ultrahigh speed gastrointestinal Optical Coherence Tomography imaging |
| title_sort | development and investigation of devices for ultrahigh speed gastrointestinal optical coherence tomography imaging |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/118085 |
| work_keys_str_mv | AT liangkaicheng developmentandinvestigationofdevicesforultrahighspeedgastrointestinalopticalcoherencetomographyimaging |