Prototyping a precision oncology 3.0 rapid learning platform

Background: We describe a prototype implementation of a platform that could underlie a Precision Oncology Rapid Learning system. Results: We describe the prototype platform, and examine some important issues and details. In the Appendix we provide a complete walk-through of the prototype platform....

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Bibliographic Details
Main Authors: Sweetnam, Connor, Mocellin, Simone, Krauthammer, Michael, Baertsch, Robert, Shrager, Jeff, Knopf, Nathaniel D.
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Language:English
Published: BioMed Central 2018
Online Access:http://hdl.handle.net/1721.1/118317
Description
Summary:Background: We describe a prototype implementation of a platform that could underlie a Precision Oncology Rapid Learning system. Results: We describe the prototype platform, and examine some important issues and details. In the Appendix we provide a complete walk-through of the prototype platform. Conclusions: The design choices made in this implementation rest upon ten constitutive hypotheses, which, taken together, define a particular view of how a rapid learning medical platform might be defined, organized, and implemented. Keywords: Natural language processing, Precision oncology, Controlled natural language, Nanopublication, Treatment reasoning, Rapid learning, Tumor boards, Targeted therapies