Manipulating memory in space and time
One of the most fascinating aspects of an animal’s brain is its ability to acquire new information from experience and retain this information over time as memory. The search for physical correlates of memory, the memory engram, has been a longstanding endeavor in modern neurobiology. Recent advance...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/118395 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1826208410681475072 |
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| author | Roy, Dheeraj Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Roy, Dheeraj Tonegawa, Susumu |
| author_sort | Roy, Dheeraj |
| collection | MIT |
| description | One of the most fascinating aspects of an animal’s brain is its ability to acquire new information from experience and retain this information over time as memory. The search for physical correlates of memory, the memory engram, has been a longstanding endeavor in modern neurobiology. Recent advances in transgenic and optogenetic tools have enabled the identification, visualization, and manipulations of natural, sensory-evoked, engram cells for a specific memory residing in specific brain regions. These studies are paving the way not only to understand memory mechanisms in unprecedented detail, but also to repair the abnormal state of mind associated with memory by engineering. |
| first_indexed | 2024-09-23T14:05:19Z |
| format | Article |
| id | mit-1721.1/118395 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:05:19Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1183952022-10-01T19:07:27Z Manipulating memory in space and time Roy, Dheeraj Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Tonegawa S Roy, Dheeraj Tonegawa, Susumu One of the most fascinating aspects of an animal’s brain is its ability to acquire new information from experience and retain this information over time as memory. The search for physical correlates of memory, the memory engram, has been a longstanding endeavor in modern neurobiology. Recent advances in transgenic and optogenetic tools have enabled the identification, visualization, and manipulations of natural, sensory-evoked, engram cells for a specific memory residing in specific brain regions. These studies are paving the way not only to understand memory mechanisms in unprecedented detail, but also to repair the abnormal state of mind associated with memory by engineering. 2018-10-09T17:44:04Z 2018-10-09T17:44:04Z 2017-06 Article http://purl.org/eprint/type/JournalArticle 2352-1546 http://hdl.handle.net/1721.1/118395 Roy, Dheeraj S, and Susumu Tonegawa. “Manipulating Memory in Space and Time.” Current Opinion in Behavioral Sciences 17 (October 2017): 1–6 © 2017 Elsevier Ltd https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-2839-8228 en_US https://doi.org/10.1016/j.cobeha.2017.05.020 Current Opinion in Behavioral Sciences Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Prof. Tonegawa via Courtney Crummett |
| spellingShingle | Roy, Dheeraj Tonegawa, Susumu Manipulating memory in space and time |
| title | Manipulating memory in space and time |
| title_full | Manipulating memory in space and time |
| title_fullStr | Manipulating memory in space and time |
| title_full_unstemmed | Manipulating memory in space and time |
| title_short | Manipulating memory in space and time |
| title_sort | manipulating memory in space and time |
| url | http://hdl.handle.net/1721.1/118395 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-2839-8228 |
| work_keys_str_mv | AT roydheeraj manipulatingmemoryinspaceandtime AT tonegawasusumu manipulatingmemoryinspaceandtime |