Task-dependent representations of stimulus and choice in mouse parietal cortex
The posterior parietal cortex (PPC) has been implicated in perceptual decisions, but whether its role is specific to sensory processing or sensorimotor transformation is not well understood. Here, we trained mice to perform a go/no-go visual discrimination task and imaged the activity of neurons in...
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| Format: | Article |
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Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/1721.1/118416 https://orcid.org/0000-0002-5547-0769 https://orcid.org/0000-0003-2442-5671 |
| _version_ | 1826213442578546688 |
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| author | Sur, Mriganka Pho, Gerald N Goard, Michael Woodson, Jonathan Crawford, Benjamin C |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Sur, Mriganka Pho, Gerald N Goard, Michael Woodson, Jonathan Crawford, Benjamin C |
| author_sort | Sur, Mriganka |
| collection | MIT |
| description | The posterior parietal cortex (PPC) has been implicated in perceptual decisions, but whether its role is specific to sensory processing or sensorimotor transformation is not well understood. Here, we trained mice to perform a go/no-go visual discrimination task and imaged the activity of neurons in primary visual cortex (V1) and PPC during engaged behavior and passive viewing. Unlike V1 neurons, which respond robustly to stimuli in both conditions, most PPC neurons respond exclusively during task engagement. To test whether signals in PPC primarily encoded the stimulus or the animal's impending choice, we image the same neurons before and after re-training mice with a reversed sensorimotor contingency. Unlike V1 neurons, most PPC neurons reflect the animal's choice of the new target stimulus after re-training. Mouse PPC is therefore strongly task-dependent, reflects choice more than stimulus, and may play a role in the transformation of visual inputs into motor commands. |
| first_indexed | 2024-09-23T15:49:17Z |
| format | Article |
| id | mit-1721.1/118416 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T15:49:17Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1184162022-10-02T04:20:11Z Task-dependent representations of stimulus and choice in mouse parietal cortex Sur, Mriganka Pho, Gerald N Goard, Michael Woodson, Jonathan Crawford, Benjamin C Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Pho, Gerald N Goard, Michael Woodson, Jonathan Crawford, Benjamin C Sur, Mriganka The posterior parietal cortex (PPC) has been implicated in perceptual decisions, but whether its role is specific to sensory processing or sensorimotor transformation is not well understood. Here, we trained mice to perform a go/no-go visual discrimination task and imaged the activity of neurons in primary visual cortex (V1) and PPC during engaged behavior and passive viewing. Unlike V1 neurons, which respond robustly to stimuli in both conditions, most PPC neurons respond exclusively during task engagement. To test whether signals in PPC primarily encoded the stimulus or the animal's impending choice, we image the same neurons before and after re-training mice with a reversed sensorimotor contingency. Unlike V1 neurons, most PPC neurons reflect the animal's choice of the new target stimulus after re-training. Mouse PPC is therefore strongly task-dependent, reflects choice more than stimulus, and may play a role in the transformation of visual inputs into motor commands. 2018-10-10T16:10:07Z 2018-10-10T16:10:07Z 2018-07 2017-09 2018-10-10T15:19:43Z Article http://purl.org/eprint/type/JournalArticle 2041-1723 http://hdl.handle.net/1721.1/118416 Pho, Gerald N., Michael J. Goard, Jonathan Woodson, Benjamin Crawford, and Mriganka Sur. “Task-Dependent Representations of Stimulus and Choice in Mouse Parietal Cortex.” Nature Communications 9, no. 1 (July 3, 2018). https://orcid.org/0000-0002-5547-0769 https://orcid.org/0000-0003-2442-5671 http://dx.doi.org/10.1038/s41467-018-05012-y Nature Communications Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature |
| spellingShingle | Sur, Mriganka Pho, Gerald N Goard, Michael Woodson, Jonathan Crawford, Benjamin C Task-dependent representations of stimulus and choice in mouse parietal cortex |
| title | Task-dependent representations of stimulus and choice in mouse parietal cortex |
| title_full | Task-dependent representations of stimulus and choice in mouse parietal cortex |
| title_fullStr | Task-dependent representations of stimulus and choice in mouse parietal cortex |
| title_full_unstemmed | Task-dependent representations of stimulus and choice in mouse parietal cortex |
| title_short | Task-dependent representations of stimulus and choice in mouse parietal cortex |
| title_sort | task dependent representations of stimulus and choice in mouse parietal cortex |
| url | http://hdl.handle.net/1721.1/118416 https://orcid.org/0000-0002-5547-0769 https://orcid.org/0000-0003-2442-5671 |
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