Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes
Chromosome mis-segregation leads to aneuploidy, a condition in which cells harbor an imbalanced chromosome number. Several lines of evidence strongly indicate that aneuploidy triggers genome instability, ultimately generating cells with complex karyotypes that arrest their proliferation. Isolation a...
| Main Authors: | , , |
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| Format: | Article |
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MyJoVE Corporation
2018
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| Online Access: | http://hdl.handle.net/1721.1/118619 https://orcid.org/0000-0002-1501-6190 |