Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay
Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. H...
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/118752 https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1826188615381680128 |
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| author | Yamamoto, Jun Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Yamamoto, Jun Tonegawa, Susumu |
| author_sort | Yamamoto, Jun |
| collection | MIT |
| description | Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. Here we show that ripple bursts in CA1 and medial entorhinal cortex (MEC) are temporally associated. An inhibition of MECIII input to CA1 during quiet awake reduced ripple bursts in CA1 and restricted the spatial coverage of replays to a shorter distance corresponding to single ripple events. The reduction did not occur with MECIII input inhibition during slow-wave sleep. Inhibition of CA3 activity suppressed ripples and replays in CA1 regardless of behavioral state. Thus, MECIII input to CA1 is crucial for ripple bursts and long-range replays specifically in quiet awake, whereas CA3 input is essential for both, regardless of behavioral state. Yamamoto and Tonegawa aim to determine the contribution of MECIII and CA3 inputs to hippocampal ripples and replays. They found differential roles of MECIII and CA3 inputs on CA1 ripples and replays during animal's different behavioral states. |
| first_indexed | 2024-09-23T08:02:26Z |
| format | Article |
| id | mit-1721.1/118752 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:02:26Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1187522022-09-23T10:28:42Z Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay Yamamoto, Jun Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Yamamoto, Jun Tonegawa, Susumu Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. Here we show that ripple bursts in CA1 and medial entorhinal cortex (MEC) are temporally associated. An inhibition of MECIII input to CA1 during quiet awake reduced ripple bursts in CA1 and restricted the spatial coverage of replays to a shorter distance corresponding to single ripple events. The reduction did not occur with MECIII input inhibition during slow-wave sleep. Inhibition of CA3 activity suppressed ripples and replays in CA1 regardless of behavioral state. Thus, MECIII input to CA1 is crucial for ripple bursts and long-range replays specifically in quiet awake, whereas CA3 input is essential for both, regardless of behavioral state. Yamamoto and Tonegawa aim to determine the contribution of MECIII and CA3 inputs to hippocampal ripples and replays. They found differential roles of MECIII and CA3 inputs on CA1 ripples and replays during animal's different behavioral states. RIKEN Brain Science Institute Howard Hughes Medical Institute JPB Foundation 2018-10-23T15:07:51Z 2018-10-23T15:07:51Z 2017-09 2018-10-16T13:09:26Z Article http://purl.org/eprint/type/JournalArticle 08966273 http://hdl.handle.net/1721.1/118752 Yamamoto, Jun, and Susumu Tonegawa. “Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay.” Neuron 96, no. 1 (September 2017): 217–227.e4. https://orcid.org/0000-0003-2839-8228 http://dx.doi.org/10.1016/J.NEURON.2017.09.017 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Yamamoto, Jun Tonegawa, Susumu Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay |
| title | Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay |
| title_full | Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay |
| title_fullStr | Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay |
| title_full_unstemmed | Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay |
| title_short | Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay |
| title_sort | direct medial entorhinal cortex input to hippocampal ca1 is crucial for extended quiet awake replay |
| url | http://hdl.handle.net/1721.1/118752 https://orcid.org/0000-0003-2839-8228 |
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