Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories
The formation and retrieval of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells (engram cells) by a common set of neural circuits, but this hypothesis has not been established. The medial temporal-lobe system is essential for the format...
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/118753 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0003-1982-634X https://orcid.org/0000-0002-2419-794X https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1826207436270206976 |
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| author | Obata, Yuichi Yoshiki, Atsushi Roy, Dheeraj Kitamura, Takashi Okuyama, Teruhiro Kitamura, Sachie Ogawa Sun, Chen Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Obata, Yuichi Yoshiki, Atsushi Roy, Dheeraj Kitamura, Takashi Okuyama, Teruhiro Kitamura, Sachie Ogawa Sun, Chen Tonegawa, Susumu |
| author_sort | Obata, Yuichi |
| collection | MIT |
| description | The formation and retrieval of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells (engram cells) by a common set of neural circuits, but this hypothesis has not been established. The medial temporal-lobe system is essential for the formation and retrieval of episodic memory for which individual hippocampal subfields and entorhinal cortex layers contribute by carrying out specific functions. One subfield whose function is poorly known is the subiculum. Here, we show that dorsal subiculum and the circuit, CA1 to dorsal subiculum to medial entorhinal cortex layer 5, play a crucial role selectively in the retrieval of episodic memories. Conversely, the direct CA1 to medial entorhinal cortex layer 5 circuit is essential specifically for memory formation. Our data suggest that the subiculum-containing detour loop is dedicated to meet the requirements associated with recall such as rapid memory updating and retrieval-driven instinctive fear responses. |
| first_indexed | 2024-09-23T13:49:38Z |
| format | Article |
| id | mit-1721.1/118753 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:49:38Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1187532022-09-28T16:27:26Z Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories Obata, Yuichi Yoshiki, Atsushi Roy, Dheeraj Kitamura, Takashi Okuyama, Teruhiro Kitamura, Sachie Ogawa Sun, Chen Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Roy, Dheeraj Kitamura, Takashi Okuyama, Teruhiro Kitamura, Sachie Ogawa Sun, Chen Tonegawa, Susumu The formation and retrieval of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells (engram cells) by a common set of neural circuits, but this hypothesis has not been established. The medial temporal-lobe system is essential for the formation and retrieval of episodic memory for which individual hippocampal subfields and entorhinal cortex layers contribute by carrying out specific functions. One subfield whose function is poorly known is the subiculum. Here, we show that dorsal subiculum and the circuit, CA1 to dorsal subiculum to medial entorhinal cortex layer 5, play a crucial role selectively in the retrieval of episodic memories. Conversely, the direct CA1 to medial entorhinal cortex layer 5 circuit is essential specifically for memory formation. Our data suggest that the subiculum-containing detour loop is dedicated to meet the requirements associated with recall such as rapid memory updating and retrieval-driven instinctive fear responses. RIKEN Brain Science Institute Howard Hughes Medical Institute JPB Foundation 2018-10-23T15:23:38Z 2018-10-23T15:23:38Z 2017-08 2018-10-16T13:05:11Z Article http://purl.org/eprint/type/JournalArticle 00928674 http://hdl.handle.net/1721.1/118753 Roy, Dheeraj S., Takashi Kitamura, Teruhiro Okuyama, Sachie K. Ogawa, Chen Sun, Yuichi Obata, Atsushi Yoshiki, and Susumu Tonegawa. “Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories.” Cell 170, no. 5 (August 2017): 1000–1012.e19. https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0003-1982-634X https://orcid.org/0000-0002-2419-794X https://orcid.org/0000-0003-2839-8228 http://dx.doi.org/10.1016/J.CELL.2017.07.013 Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Obata, Yuichi Yoshiki, Atsushi Roy, Dheeraj Kitamura, Takashi Okuyama, Teruhiro Kitamura, Sachie Ogawa Sun, Chen Tonegawa, Susumu Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories |
| title | Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories |
| title_full | Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories |
| title_fullStr | Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories |
| title_full_unstemmed | Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories |
| title_short | Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories |
| title_sort | distinct neural circuits for the formation and retrieval of episodic memories |
| url | http://hdl.handle.net/1721.1/118753 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0003-1982-634X https://orcid.org/0000-0002-2419-794X https://orcid.org/0000-0003-2839-8228 |
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