Turning omics data into therapeutic insights
Omics technologies have made it easier and cheaper to evaluate thousands of biological molecules at once. These advances have led to novel therapies approved for use in the clinic, elucidated the mechanisms behind disease-associated mutations, led to increased accuracy in disease subtyping and perso...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/118810 https://orcid.org/0000-0001-6156-5046 https://orcid.org/0000-0001-9249-8181 |
| _version_ | 1826197987300212736 |
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| author | Kedaigle, Amanda Joy Fraenkel, Ernest |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Kedaigle, Amanda Joy Fraenkel, Ernest |
| author_sort | Kedaigle, Amanda Joy |
| collection | MIT |
| description | Omics technologies have made it easier and cheaper to evaluate thousands of biological molecules at once. These advances have led to novel therapies approved for use in the clinic, elucidated the mechanisms behind disease-associated mutations, led to increased accuracy in disease subtyping and personalized medicine, and revealed novel uses and treatment regimes for existing drugs through drug repurposing and pharmacology studies. In this review, we summarize some of these milestones and discuss the potential of integrative analyses that combine multiple data types for further advances. |
| first_indexed | 2024-09-23T10:57:06Z |
| format | Article |
| id | mit-1721.1/118810 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:57:06Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1188102022-10-01T00:09:29Z Turning omics data into therapeutic insights Kedaigle, Amanda Joy Fraenkel, Ernest Massachusetts Institute of Technology. Department of Biological Engineering Fraenkel, Ernest Kedaigle, Amanda Joy Fraenkel, Ernest Omics technologies have made it easier and cheaper to evaluate thousands of biological molecules at once. These advances have led to novel therapies approved for use in the clinic, elucidated the mechanisms behind disease-associated mutations, led to increased accuracy in disease subtyping and personalized medicine, and revealed novel uses and treatment regimes for existing drugs through drug repurposing and pharmacology studies. In this review, we summarize some of these milestones and discuss the potential of integrative analyses that combine multiple data types for further advances. National Institutes of Health (U.S.) (Grant R01 NS089076) 2018-10-30T18:47:58Z 2018-10-30T18:47:58Z 2018-08 Article http://purl.org/eprint/type/JournalArticle 1471-4892 http://hdl.handle.net/1721.1/118810 Kedaigle, Amanda, and Ernest Fraenkel. “Turning Omics Data into Therapeutic Insights.” Current Opinion in Pharmacology, vol. 42, Oct. 2018, pp. 95–101. https://orcid.org/0000-0001-6156-5046 https://orcid.org/0000-0001-9249-8181 en_US https://doi.org/10.1016/j.coph.2018.08.006 Current Opinion in Pharmacology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Prof. Fraenkel via Howard Silver |
| spellingShingle | Kedaigle, Amanda Joy Fraenkel, Ernest Turning omics data into therapeutic insights |
| title | Turning omics data into therapeutic insights |
| title_full | Turning omics data into therapeutic insights |
| title_fullStr | Turning omics data into therapeutic insights |
| title_full_unstemmed | Turning omics data into therapeutic insights |
| title_short | Turning omics data into therapeutic insights |
| title_sort | turning omics data into therapeutic insights |
| url | http://hdl.handle.net/1721.1/118810 https://orcid.org/0000-0001-6156-5046 https://orcid.org/0000-0001-9249-8181 |
| work_keys_str_mv | AT kedaigleamandajoy turningomicsdataintotherapeuticinsights AT fraenkelernest turningomicsdataintotherapeuticinsights |