Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelial cells to enter into...
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| Format: | Article |
| Language: | English |
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Higher Education Press
2018
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| Online Access: | http://hdl.handle.net/1721.1/118855 https://orcid.org/0000-0002-0895-3557 |
| _version_ | 1811071104526057472 |
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| author | Zhang, Yun Weinberg, Robert A |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Zhang, Yun Weinberg, Robert A |
| author_sort | Zhang, Yun |
| collection | MIT |
| description | The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelial cells to enter into a series of phenotypic states arrayed along the epithelial-mesenchymal phenotypic axis. These cell states display distinctive cellular characteristics, including stemness, invasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer metastasis and relapse. Currently we still lack a coherent overview of the molecular and biochemical mechanisms inducing cells to enter various states along the epithelial-mesenchymal phenotypic spectrum. An improved understanding of the dynamic and plastic nature of the EMT program has the potential to yield novel therapies targeting this cellular program that may aid in the management of high-grade malignancies. Keywords: epithelial-to-mesenchymal transition; cancer metastasis; cancer stem cell |
| first_indexed | 2024-09-23T08:46:08Z |
| format | Article |
| id | mit-1721.1/118855 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:46:08Z |
| publishDate | 2018 |
| publisher | Higher Education Press |
| record_format | dspace |
| spelling | mit-1721.1/1188552022-09-30T11:08:03Z Epithelial-to-mesenchymal transition in cancer: complexity and opportunities Zhang, Yun Weinberg, Robert A Massachusetts Institute of Technology. Department of Biology Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology) Weinberg, Robert A The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelial cells to enter into a series of phenotypic states arrayed along the epithelial-mesenchymal phenotypic axis. These cell states display distinctive cellular characteristics, including stemness, invasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer metastasis and relapse. Currently we still lack a coherent overview of the molecular and biochemical mechanisms inducing cells to enter various states along the epithelial-mesenchymal phenotypic spectrum. An improved understanding of the dynamic and plastic nature of the EMT program has the potential to yield novel therapies targeting this cellular program that may aid in the management of high-grade malignancies. Keywords: epithelial-to-mesenchymal transition; cancer metastasis; cancer stem cell National Institutes of Health (U.S.) (Grant R01- CA078461) 2018-11-02T19:25:26Z 2018-11-02T19:25:26Z 2018-07 2018-04 2018-10-25T05:12:15Z Article http://purl.org/eprint/type/JournalArticle 2095-0217 2095-0225 http://hdl.handle.net/1721.1/118855 Zhang, Yun and Robert A. Weinberg. “Epithelial-to-Mesenchymal Transition in Cancer: Complexity and Opportunities.” Frontiers of Medicine 12, 4 (July 2018): 361–373 © 2018 The Author(s) https://orcid.org/0000-0002-0895-3557 en https://doi.org/10.1007/s11684-018-0656-6 Frontiers of Medicine The Author(s) application/pdf Higher Education Press |
| spellingShingle | Zhang, Yun Weinberg, Robert A Epithelial-to-mesenchymal transition in cancer: complexity and opportunities |
| title | Epithelial-to-mesenchymal transition in cancer: complexity and opportunities |
| title_full | Epithelial-to-mesenchymal transition in cancer: complexity and opportunities |
| title_fullStr | Epithelial-to-mesenchymal transition in cancer: complexity and opportunities |
| title_full_unstemmed | Epithelial-to-mesenchymal transition in cancer: complexity and opportunities |
| title_short | Epithelial-to-mesenchymal transition in cancer: complexity and opportunities |
| title_sort | epithelial to mesenchymal transition in cancer complexity and opportunities |
| url | http://hdl.handle.net/1721.1/118855 https://orcid.org/0000-0002-0895-3557 |
| work_keys_str_mv | AT zhangyun epithelialtomesenchymaltransitionincancercomplexityandopportunities AT weinbergroberta epithelialtomesenchymaltransitionincancercomplexityandopportunities |