Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole
Background The relatively fast selection of symbiotic bacteria within hosts and the potential transmission of these bacteria across generations of hosts raise the question of whether interactions between host and bacteria support emergent adaptive capabilities beyond those of germ-f...
| Autors principals: | , , , |
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| Altres autors: | |
| Format: | Article |
| Idioma: | English |
| Publicat: |
Biomed Central Ltd
2018
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| Accés en línia: | http://hdl.handle.net/1721.1/118856 |
| _version_ | 1826213881825984512 |
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| author | Osmanovic, Dino Kessler, David A Rabin, Yitzhak Soen, Yoav |
| author2 | Massachusetts Institute of Technology. Department of Physics |
| author_facet | Massachusetts Institute of Technology. Department of Physics Osmanovic, Dino Kessler, David A Rabin, Yitzhak Soen, Yoav |
| author_sort | Osmanovic, Dino |
| collection | MIT |
| description | Background
The relatively fast selection of symbiotic bacteria within hosts and the potential transmission of these bacteria across generations of hosts raise the question of whether interactions between host and bacteria support emergent adaptive capabilities beyond those of germ-free hosts.
Results
To investigate possibilities for emergent adaptations that may distinguish composite host-microbiome systems from germ-free hosts, we introduce a population genetics model of a host-microbiome system with vertical transmission of bacteria. The host and its bacteria are jointly exposed to a toxic agent, creating a toxic stress that can be alleviated by selection of resistant individuals and by secretion of a detoxification agent (“detox”). We show that toxic exposure in one generation of hosts leads to selection of resistant bacteria, which in turn, increases the toxic tolerance of the host’s offspring. Prolonged exposure to toxin over many host generations promotes anadditional form of emergent adaptation due to selection of hosts based on detox produced by their bacterial community as a whole (as opposed to properties of individual bacteria).
Conclusions
These findings show that interactions between pure Darwinian selections of host and its bacteria can give rise to emergent adaptive capabilities, including Lamarckian-like adaptation of the host-microbiome system.
Reviewers
This article was reviewed by Eugene Koonin, Yuri Wolf and Philippe Huneman. |
| first_indexed | 2024-09-23T15:56:20Z |
| format | Article |
| id | mit-1721.1/118856 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:56:20Z |
| publishDate | 2018 |
| publisher | Biomed Central Ltd |
| record_format | dspace |
| spelling | mit-1721.1/1188562022-09-29T17:10:26Z Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole Osmanovic, Dino Kessler, David A Rabin, Yitzhak Soen, Yoav Massachusetts Institute of Technology. Department of Physics Kessler, David A Background The relatively fast selection of symbiotic bacteria within hosts and the potential transmission of these bacteria across generations of hosts raise the question of whether interactions between host and bacteria support emergent adaptive capabilities beyond those of germ-free hosts. Results To investigate possibilities for emergent adaptations that may distinguish composite host-microbiome systems from germ-free hosts, we introduce a population genetics model of a host-microbiome system with vertical transmission of bacteria. The host and its bacteria are jointly exposed to a toxic agent, creating a toxic stress that can be alleviated by selection of resistant individuals and by secretion of a detoxification agent (“detox”). We show that toxic exposure in one generation of hosts leads to selection of resistant bacteria, which in turn, increases the toxic tolerance of the host’s offspring. Prolonged exposure to toxin over many host generations promotes anadditional form of emergent adaptation due to selection of hosts based on detox produced by their bacterial community as a whole (as opposed to properties of individual bacteria). Conclusions These findings show that interactions between pure Darwinian selections of host and its bacteria can give rise to emergent adaptive capabilities, including Lamarckian-like adaptation of the host-microbiome system. Reviewers This article was reviewed by Eugene Koonin, Yuri Wolf and Philippe Huneman. 2018-11-02T19:35:26Z 2018-11-02T19:35:26Z 2018-10 2018-03 2018-10-28T14:26:09Z Article http://purl.org/eprint/type/JournalArticle 1745-6150 http://hdl.handle.net/1721.1/118856 Osmanovic, Dino et al. "Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole." 2018, 13 (October 2018): 24 © 2018 The Author(s) en https://doi.org/10.1186/s13062-018-0224-7 Biology Direct Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ The Author(s). application/pdf Biomed Central Ltd BioMed Central |
| spellingShingle | Osmanovic, Dino Kessler, David A Rabin, Yitzhak Soen, Yoav Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole |
| title | Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole |
| title_full | Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole |
| title_fullStr | Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole |
| title_full_unstemmed | Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole |
| title_short | Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole |
| title_sort | darwinian selection of host and bacteria supports emergence of lamarckian like adaptation of the system as a whole |
| url | http://hdl.handle.net/1721.1/118856 |
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