One-year mortality after recovery from critical illness: A retrospective cohort study
Rationale Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding post-hospital discharge outcomes of patients from the intensive care unit, which may be important when counseling patients and families....
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Public Library of Science
2018
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| Online Access: | http://hdl.handle.net/1721.1/118877 https://orcid.org/0000-0002-2573-388X https://orcid.org/0000-0001-5135-8588 |
| _version_ | 1826215200855949312 |
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| author | Stone, David J. Lokhandwala, Sharukh McCague, Ned J Chahin, Abdullah Escobar Restrepo, Braiam Feng, Mengling Ghassemi, Mohammad Mahdi Celi, Leo Anthony G. |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Stone, David J. Lokhandwala, Sharukh McCague, Ned J Chahin, Abdullah Escobar Restrepo, Braiam Feng, Mengling Ghassemi, Mohammad Mahdi Celi, Leo Anthony G. |
| author_sort | Stone, David J. |
| collection | MIT |
| description | Rationale Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding post-hospital discharge outcomes of patients from the intensive care unit, which may be important when counseling patients and families. Objective We sought to determine which factors among patients who survived for at least 30 days post-ICU admission are associated with one-year mortality. Methods Single-center, longitudinal retrospective cohort study of all ICU patients admitted to a tertiary-care academic medical center from 2001–2012 who survived 30 days from ICU admission. Cox’s proportional hazards model was used to identify the variables that are associated with one-year mortality. The primary outcome was one-year mortality. Results 32,420 patients met the inclusion criteria and were included in the study. Among patients who survived to 30 days, 28,583 (88.2%) survived for greater than one year, whereas 3,837 (11.8%) did not. Variables associated with decreased one-year survival include: increased age, malignancy, number of hospital admissions within the prior year, duration of mechanical ventilation and vasoactive agent use, sepsis, history of congestive heart failure, end-stage renal disease, cirrhosis, chronic obstructive pulmonary disease, and the need for renal replacement therapy. Numerous effect modifications between these factors were found. Conclusion Among survivors of critical illness, a significant number survive less than one year. More research is needed to help clinicians accurately identify those patients who, despite surviving their acute illness, are likely to suffer one-year mortality, and thereby to improve the quality of the decisions and care that impact this outcome. |
| first_indexed | 2024-09-23T16:18:53Z |
| format | Article |
| id | mit-1721.1/118877 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:18:53Z |
| publishDate | 2018 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/1188772022-09-29T19:30:33Z One-year mortality after recovery from critical illness: A retrospective cohort study Stone, David J. Lokhandwala, Sharukh McCague, Ned J Chahin, Abdullah Escobar Restrepo, Braiam Feng, Mengling Ghassemi, Mohammad Mahdi Celi, Leo Anthony G. Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Center for Transportation & Logistics Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Lokhandwala, Sharukh McCague, Ned J Chahin, Abdullah Escobar Restrepo, Braiam Feng, Mengling Ghassemi, Mohammad Mahdi Celi, Leo Anthony G. Rationale Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding post-hospital discharge outcomes of patients from the intensive care unit, which may be important when counseling patients and families. Objective We sought to determine which factors among patients who survived for at least 30 days post-ICU admission are associated with one-year mortality. Methods Single-center, longitudinal retrospective cohort study of all ICU patients admitted to a tertiary-care academic medical center from 2001–2012 who survived 30 days from ICU admission. Cox’s proportional hazards model was used to identify the variables that are associated with one-year mortality. The primary outcome was one-year mortality. Results 32,420 patients met the inclusion criteria and were included in the study. Among patients who survived to 30 days, 28,583 (88.2%) survived for greater than one year, whereas 3,837 (11.8%) did not. Variables associated with decreased one-year survival include: increased age, malignancy, number of hospital admissions within the prior year, duration of mechanical ventilation and vasoactive agent use, sepsis, history of congestive heart failure, end-stage renal disease, cirrhosis, chronic obstructive pulmonary disease, and the need for renal replacement therapy. Numerous effect modifications between these factors were found. Conclusion Among survivors of critical illness, a significant number survive less than one year. More research is needed to help clinicians accurately identify those patients who, despite surviving their acute illness, are likely to suffer one-year mortality, and thereby to improve the quality of the decisions and care that impact this outcome. National Institute of Biomedical Imaging and Bioengineering (U.S.) (grant R01EB017205-01A1) A*STAR (Graduate Scholarship) National Institutes of Health (U.S.) (grant T32 HL007287-39) National Heart, Lung, and Blood Institute Philips Healthcare Nederland 2018-11-05T15:37:44Z 2018-11-05T15:37:44Z 2018-05 2017-11 2018-10-12T15:58:35Z Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/118877 Lokhandwala, Sharukh, Ned McCague, Abdullah Chahin, Braiam Escobar, Mengling Feng, Mohammad M. Ghassemi, David J. Stone, and Leo Anthony Celi. “One-Year Mortality after Recovery from Critical Illness: A Retrospective Cohort Study.” Edited by Chiara Lazzeri. PLOS ONE 13, no. 5 (May 11, 2018): e0197226. https://orcid.org/0000-0002-2573-388X https://orcid.org/0000-0001-5135-8588 http://dx.doi.org/10.1371/journal.pone.0197226 PLOS ONE Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science PLoS |
| spellingShingle | Stone, David J. Lokhandwala, Sharukh McCague, Ned J Chahin, Abdullah Escobar Restrepo, Braiam Feng, Mengling Ghassemi, Mohammad Mahdi Celi, Leo Anthony G. One-year mortality after recovery from critical illness: A retrospective cohort study |
| title | One-year mortality after recovery from critical illness: A retrospective cohort study |
| title_full | One-year mortality after recovery from critical illness: A retrospective cohort study |
| title_fullStr | One-year mortality after recovery from critical illness: A retrospective cohort study |
| title_full_unstemmed | One-year mortality after recovery from critical illness: A retrospective cohort study |
| title_short | One-year mortality after recovery from critical illness: A retrospective cohort study |
| title_sort | one year mortality after recovery from critical illness a retrospective cohort study |
| url | http://hdl.handle.net/1721.1/118877 https://orcid.org/0000-0002-2573-388X https://orcid.org/0000-0001-5135-8588 |
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