Contrast enhancement of propagation based X-ray phase contrast imaging
We demonstrate a quantitative X-ray phase contrast imaging (XPCI) technique derived from propagation dependent phase change. We assume that the absorption and phase components are correlated and solve the Transport of Intensity Equation (TIE). The experimental setup is simple compared to other XPCI...
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| Format: | Article |
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SPIE
2018
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| Online Access: | http://hdl.handle.net/1721.1/119019 https://orcid.org/0000-0002-5770-1241 https://orcid.org/0000-0003-4161-9574 https://orcid.org/0000-0002-4140-1404 |
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| author | Pan, Adam Xu, Ling Petruccelli, Jon C. Gupta, Rajiv Barbastathis, George |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Pan, Adam Xu, Ling Petruccelli, Jon C. Gupta, Rajiv Barbastathis, George |
| author_sort | Pan, Adam |
| collection | MIT |
| description | We demonstrate a quantitative X-ray phase contrast imaging (XPCI) technique derived from propagation dependent phase change. We assume that the absorption and phase components are correlated and solve the Transport of Intensity Equation (TIE). The experimental setup is simple compared to other XPCI techniques; the only requirements are a micro-focus X-ray source with sufficient temporal coherence and an X-ray detector of sufficient spatial resolution. This method was demonstrated in three scenarios, the first of which entails identification of an index-matched sphere. A rubber and nylon sphere were immersed in water and imaged. While the rubber sphere could be plainly seen on a radiograph, the nylon sphere was only visible in the phase reconstruction. Next, the technique was applied to differentiating liquid samples. In this scenario, three liquid samples (acetone, water, and hydrogen peroxide) were analyzed using both conventional computed tomography (CT) and phase contrast CT. While conventional CT was capable of differentiating between acetone and the other two liquids, it failed to distinguish between water and hydrogen peroxide; only phase CT was capable of differentiating all three samples. Finally, the technique was applied to CT imaging of a human artery specimen with extensive atherosclerotic plaque. This scenario demonstrated the increased sensitivity to soft tissue compared to conventional CT; it also uncovered some drawbacks of the method, which will be the target of future work. In all cases, the signal-to-noise ratio of phase contrast was greatly enhanced relative to conventional attenuation-based imaging. Keywords: Phase retrieval, transport of intensity, X-ray imaging |
| first_indexed | 2024-09-23T16:04:49Z |
| format | Article |
| id | mit-1721.1/119019 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:04:49Z |
| publishDate | 2018 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/1190192022-10-02T06:14:09Z Contrast enhancement of propagation based X-ray phase contrast imaging Pan, Adam Xu, Ling Petruccelli, Jon C. Gupta, Rajiv Barbastathis, George Institute for Medical Engineering and Science Massachusetts Institute of Technology. Department of Mechanical Engineering Pan, Adam Xu, Ling Barbastathis, George We demonstrate a quantitative X-ray phase contrast imaging (XPCI) technique derived from propagation dependent phase change. We assume that the absorption and phase components are correlated and solve the Transport of Intensity Equation (TIE). The experimental setup is simple compared to other XPCI techniques; the only requirements are a micro-focus X-ray source with sufficient temporal coherence and an X-ray detector of sufficient spatial resolution. This method was demonstrated in three scenarios, the first of which entails identification of an index-matched sphere. A rubber and nylon sphere were immersed in water and imaged. While the rubber sphere could be plainly seen on a radiograph, the nylon sphere was only visible in the phase reconstruction. Next, the technique was applied to differentiating liquid samples. In this scenario, three liquid samples (acetone, water, and hydrogen peroxide) were analyzed using both conventional computed tomography (CT) and phase contrast CT. While conventional CT was capable of differentiating between acetone and the other two liquids, it failed to distinguish between water and hydrogen peroxide; only phase CT was capable of differentiating all three samples. Finally, the technique was applied to CT imaging of a human artery specimen with extensive atherosclerotic plaque. This scenario demonstrated the increased sensitivity to soft tissue compared to conventional CT; it also uncovered some drawbacks of the method, which will be the target of future work. In all cases, the signal-to-noise ratio of phase contrast was greatly enhanced relative to conventional attenuation-based imaging. Keywords: Phase retrieval, transport of intensity, X-ray imaging United States. Department of Homeland Security (Contract HSHQDC-11-C-00083) 2018-11-14T20:25:23Z 2018-11-14T20:25:23Z 2014-08 2018-10-29T15:46:23Z Article http://purl.org/eprint/type/ConferencePaper http://hdl.handle.net/1721.1/119019 Pan, Adam, et al. "Contrast Enhancement of Propagation Based X-Ray Phase Contrast Imaging."SPIE Optical Engineering + Applications, 17-21 August, 2014, San Diego, California, edited by Manuel Sanchez del Rio and Oleg Chubar, 2014, p. 92090R © 2014 SPIE https://orcid.org/0000-0002-5770-1241 https://orcid.org/0000-0003-4161-9574 https://orcid.org/0000-0002-4140-1404 http://dx.doi.org/10.1117/12.2060605 SPIE Optical Engineering + Applications Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE SPIE |
| spellingShingle | Pan, Adam Xu, Ling Petruccelli, Jon C. Gupta, Rajiv Barbastathis, George Contrast enhancement of propagation based X-ray phase contrast imaging |
| title | Contrast enhancement of propagation based X-ray phase contrast imaging |
| title_full | Contrast enhancement of propagation based X-ray phase contrast imaging |
| title_fullStr | Contrast enhancement of propagation based X-ray phase contrast imaging |
| title_full_unstemmed | Contrast enhancement of propagation based X-ray phase contrast imaging |
| title_short | Contrast enhancement of propagation based X-ray phase contrast imaging |
| title_sort | contrast enhancement of propagation based x ray phase contrast imaging |
| url | http://hdl.handle.net/1721.1/119019 https://orcid.org/0000-0002-5770-1241 https://orcid.org/0000-0003-4161-9574 https://orcid.org/0000-0002-4140-1404 |
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