Realizing ‘integral control’ in living cells: how to overcome leaky integration due to dilution?
A major problem in the design of synthetic genetic circuits is robustness to perturbations and uncertainty. Because of this, there have been significant efforts in recent years in finding approaches to implement integral control in genetic circuits. Integral controllers have the unique ability to ma...
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Royal Society Publishing
2018
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| Online Access: | http://hdl.handle.net/1721.1/119170 https://orcid.org/0000-0002-1097-0401 https://orcid.org/0000-0001-6472-8576 |