The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas
A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors. Here we review the experiences of the BRAIN Initiative Cell Census Consortium, ten pilot project...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/119192 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1826202827973722112 |
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| author | Ecker, Joseph R. Geschwind, Daniel H. Kriegstein, Arnold R. Ngai, John Osten, Pavel Polioudakis, Damon Regev, Aviv Sestan, Nenad Wickersham, Ian R. Zeng, Hongkui |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Ecker, Joseph R. Geschwind, Daniel H. Kriegstein, Arnold R. Ngai, John Osten, Pavel Polioudakis, Damon Regev, Aviv Sestan, Nenad Wickersham, Ian R. Zeng, Hongkui |
| author_sort | Ecker, Joseph R. |
| collection | MIT |
| description | A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors. Here we review the experiences of the BRAIN Initiative Cell Census Consortium, ten pilot projects funded by the U.S. BRAIN Initiative, in developing, validating, and scaling up emerging genomic and anatomical mapping technologies for creating a complete inventory of neuronal cell types and their connections in multiple species and during development. These projects lay the foundation for a larger and longer-term effort to generate whole-brain cell atlases in species including mice and humans. In this Perspective, Ecker et al. discuss the efforts of the BRAIN Initiative Cell Census Consortium, ten pilot projects whose collective goal was to develop and validate methods for generating comprehensive atlases of neuronal cell types in the mammalian brain. |
| first_indexed | 2024-09-23T12:20:33Z |
| format | Article |
| id | mit-1721.1/119192 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T12:20:33Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1191922022-09-28T07:51:00Z The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas Ecker, Joseph R. Geschwind, Daniel H. Kriegstein, Arnold R. Ngai, John Osten, Pavel Polioudakis, Damon Regev, Aviv Sestan, Nenad Wickersham, Ian R. Zeng, Hongkui Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Media Laboratory McGovern Institute for Brain Research at MIT Regev, Aviv Wickersham, Ian R. A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors. Here we review the experiences of the BRAIN Initiative Cell Census Consortium, ten pilot projects funded by the U.S. BRAIN Initiative, in developing, validating, and scaling up emerging genomic and anatomical mapping technologies for creating a complete inventory of neuronal cell types and their connections in multiple species and during development. These projects lay the foundation for a larger and longer-term effort to generate whole-brain cell atlases in species including mice and humans. In this Perspective, Ecker et al. discuss the efforts of the BRAIN Initiative Cell Census Consortium, ten pilot projects whose collective goal was to develop and validate methods for generating comprehensive atlases of neuronal cell types in the mammalian brain. BRAIN Initiative 2018-11-19T17:15:50Z 2018-11-19T17:15:50Z 2017-11 2018-11-06T13:57:45Z Article http://purl.org/eprint/type/JournalArticle 08966273 http://hdl.handle.net/1721.1/119192 Ecker, Joseph R., Daniel H. Geschwind, Arnold R. Kriegstein, John Ngai, Pavel Osten, Damon Polioudakis, Aviv Regev, Nenad Sestan, Ian R. Wickersham, and Hongkui Zeng. “The BRAIN Initiative Cell Census Consortium: Lessons Learned Toward Generating a Comprehensive Brain Cell Atlas.” Neuron 96, no. 3 (November 2017): 542–557. https://orcid.org/0000-0001-8567-2049 http://dx.doi.org/10.1016/J.NEURON.2017.10.007 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Ecker, Joseph R. Geschwind, Daniel H. Kriegstein, Arnold R. Ngai, John Osten, Pavel Polioudakis, Damon Regev, Aviv Sestan, Nenad Wickersham, Ian R. Zeng, Hongkui The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas |
| title | The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas |
| title_full | The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas |
| title_fullStr | The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas |
| title_full_unstemmed | The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas |
| title_short | The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas |
| title_sort | brain initiative cell census consortium lessons learned toward generating a comprehensive brain cell atlas |
| url | http://hdl.handle.net/1721.1/119192 https://orcid.org/0000-0001-8567-2049 |
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