Integral action with time scale separation: A mechanism for modularity in biological systems

Integral action with time scale separation: A mechanism for modularity in biological systems

Modularity is the property according to which the input/output dynamic behavior of a system does not appreciably change after interconnection with other systems. Whether modularity is a natural property of biological systems is one of the most vexing questions in systems biology and crucial for the...

Bibliografski detalji
Glavni autori:	Rivera-Ortiz, Phillip Michael, Del Vecchio, Domitilla
Daljnji autori:	Massachusetts Institute of Technology. Department of Mechanical Engineering
Format:	Članak
Izdano:	Institute of Electrical and Electronics Engineers (IEEE) 2018
Online pristup:	http://hdl.handle.net/1721.1/119201 https://orcid.org/0000-0001-6472-8576

Slični predmeti

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Time-scale separation based design of biomolecular feedback controllers
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Modularity in signaling systems
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Modular cell biology: retroactivity and insulation
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Model order reduction for Linear Noise Approximation using time-scale separation
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Time-scale separation based design of biomolecular feedback controllers (extended version)
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Approximation of the Chemical Master Equation using conditional moment closure and time-scale separation
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Approximation of the Chemical Master Equation using conditional moment closure and time-scale separation
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Reduced Linear Noise Approximation for Biochemical Reaction Networks with Time-Scale Separation: The Stochastic tQSSA⁺
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The Enhanced Finite State Projection algorithm, using conditional moment closure and time-scale separation
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A control theoretic framework for modular analysis and design of biomolecular networks
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Multi-time-scale biomolecular ‘quasi-integral’ controllers for set-point regulation and trajectory tracking
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Retroactivity Attenuation in Bio-Molecular Systems Based on Timescale Separation
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Retroactivity attenuation through signal transduction cascades
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Optimal design of phosphorylation-based insulation devices
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Synthetic biology by controller design
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An N-stage cascade of phosphorylation cycles as an insulation device for synthetic biological circuits
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Control theory meets synthetic biology
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Deterministic-Like Model Reduction for a Class of Multi-Scale Stochastic Differential Equations with Application to Biomolecular Systems
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Hitting time behavior for the solution of a stochastic differential equation
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The effect of retroactivity on the transfer function of a phosphorylation system
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Future systems and control research in synthetic biology
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Design of safety distributed control under bounded time-varying communication delay
od: Bresch-Pietri, Delphine, i dr.
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Multi-modality in gene regulatory networks with slow promoter kinetics
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Context-aware synthetic biology by controller design: Engineering the mammalian cell
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Computational Tools for the Safety Control of a Class of Piecewise Continuous Systems with Imperfect Information on a Partial Order
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Stability and Convergence of Solutions to Volterra Integral Equations on Time Scales
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A quasi-integral controller for adaptation of genetic modules to variable ribosome demand
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Modular design of biological systems
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Module and modularity – Variations and application scales in contemporary times
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Safety control of hidden mode hybrid systems
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