Next-generation biocontainment systems for engineered organisms
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/1721.1/119226 https://orcid.org/0000-0002-5560-8246 |
| _version_ | 1826208899660775424 |
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| author | Lee, Jeong Wook Chan, Clement T. Y. Slomovic, Shimyn Collins, James J. |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Lee, Jeong Wook Chan, Clement T. Y. Slomovic, Shimyn Collins, James J. |
| author_sort | Lee, Jeong Wook |
| collection | MIT |
| description | The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation. |
| first_indexed | 2024-09-23T14:14:22Z |
| format | Article |
| id | mit-1721.1/119226 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:14:22Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1192262021-05-28T18:05:24Z Next-generation biocontainment systems for engineered organisms Lee, Jeong Wook Chan, Clement T. Y. Slomovic, Shimyn Collins, James J. Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Synthetic Biology Center Collins, James J Collins, James J. The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation. Defense Threat Reduction Agency (DTRA) (Grant HDTRA1-14-1-0006) United States. Air Force Office of Scientific Research (Grant FA9550-14-1-0060) 2018-11-20T15:48:54Z 2018-11-20T15:48:54Z 2018-05 2017-05 Article http://purl.org/eprint/type/JournalArticle 1552-4450 1552-4469 http://hdl.handle.net/1721.1/119226 Lee, Jeong Wook et al. “Next-Generation Biocontainment Systems for Engineered Organisms.” Nature Chemical Biology 14, 6 (May 2018): 530–537 © 2018 Nature Publishing Group https://orcid.org/0000-0002-5560-8246 en_US https://doi.org/10.1038/s41589-018-0056-x Nature Chemical Biology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/octet-stream Nature Publishing Group Prof. Collins via Howard Silver |
| spellingShingle | Lee, Jeong Wook Chan, Clement T. Y. Slomovic, Shimyn Collins, James J. Next-generation biocontainment systems for engineered organisms |
| title | Next-generation biocontainment systems for engineered organisms |
| title_full | Next-generation biocontainment systems for engineered organisms |
| title_fullStr | Next-generation biocontainment systems for engineered organisms |
| title_full_unstemmed | Next-generation biocontainment systems for engineered organisms |
| title_short | Next-generation biocontainment systems for engineered organisms |
| title_sort | next generation biocontainment systems for engineered organisms |
| url | http://hdl.handle.net/1721.1/119226 https://orcid.org/0000-0002-5560-8246 |
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