Ten things you should know about transposable elements
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities o...
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| Materialtyp: | Artikel |
| Språk: | English |
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BioMed Central
2018
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| Länkar: | http://hdl.handle.net/1721.1/119454 |
| _version_ | 1826192327967768576 |
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| author | Bourque, Guillaume Burns, Kathleen H Gehring, Mary Gorbunova, Vera Seluanov, Andrei Hammell, Molly Imbeault, Michaël Izsvák, Zsuzsanna Levin, Henry L Macfarlan, Todd S Mager, Dixie L Feschotte, Cédric Burns, Kathleen H. Levin, Henry L. Macfarlan, Todd S. Mager, Dixie L. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Bourque, Guillaume Burns, Kathleen H Gehring, Mary Gorbunova, Vera Seluanov, Andrei Hammell, Molly Imbeault, Michaël Izsvák, Zsuzsanna Levin, Henry L Macfarlan, Todd S Mager, Dixie L Feschotte, Cédric Burns, Kathleen H. Levin, Henry L. Macfarlan, Todd S. Mager, Dixie L. |
| author_sort | Bourque, Guillaume |
| collection | MIT |
| description | Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms. |
| first_indexed | 2024-09-23T09:10:04Z |
| format | Article |
| id | mit-1721.1/119454 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:10:04Z |
| publishDate | 2018 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | mit-1721.1/1194542022-09-30T13:53:51Z Ten things you should know about transposable elements Bourque, Guillaume Burns, Kathleen H Gehring, Mary Gorbunova, Vera Seluanov, Andrei Hammell, Molly Imbeault, Michaël Izsvák, Zsuzsanna Levin, Henry L Macfarlan, Todd S Mager, Dixie L Feschotte, Cédric Burns, Kathleen H. Levin, Henry L. Macfarlan, Todd S. Mager, Dixie L. Massachusetts Institute of Technology. Department of Biology Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms. 2018-12-07T14:36:22Z 2018-12-07T14:36:22Z 2018-11 2018-11-26T10:29:55Z Article http://purl.org/eprint/type/JournalArticle 1474-760X http://hdl.handle.net/1721.1/119454 Bourque, Guillaume et al. "Ten things you should know about transposable elements." Genome Biology 19 (November 2018): 199 © 2018 The Author(s) en https://doi.org/10.1186/s13059-018-1577-z Genome Biology Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ The Author(s). application/pdf BioMed Central BioMed Central |
| spellingShingle | Bourque, Guillaume Burns, Kathleen H Gehring, Mary Gorbunova, Vera Seluanov, Andrei Hammell, Molly Imbeault, Michaël Izsvák, Zsuzsanna Levin, Henry L Macfarlan, Todd S Mager, Dixie L Feschotte, Cédric Burns, Kathleen H. Levin, Henry L. Macfarlan, Todd S. Mager, Dixie L. Ten things you should know about transposable elements |
| title | Ten things you should know about transposable elements |
| title_full | Ten things you should know about transposable elements |
| title_fullStr | Ten things you should know about transposable elements |
| title_full_unstemmed | Ten things you should know about transposable elements |
| title_short | Ten things you should know about transposable elements |
| title_sort | ten things you should know about transposable elements |
| url | http://hdl.handle.net/1721.1/119454 |
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