Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation

We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells...

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Bibliographic Details
Main Authors: Aizenberg, Joanna, Analoui, Mostafa, Andrews, Anne M., Mooney, David J., Oklu, Rahmi, Peer, Dan, Stolzoff, Michelle, Webster, Thomas J., Weiss, Paul S., Alvarez, Mario Moises, Bisker Raviv, Gili Hana, Boyden, Edward, Kamm, Roger Dale, Karp, Jeffrey, Strano, Michael S., Trujillo de Santiago, Grissel, Khademhosseini, Alireza
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Published: American Chemical Society (ACS) 2018
Online Access:http://hdl.handle.net/1721.1/119496
https://orcid.org/0000-0003-2592-7956
https://orcid.org/0000-0002-0419-3351
https://orcid.org/0000-0002-7232-304X
https://orcid.org/0000-0003-2944-808X
Description
Summary:We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events. In therapeutics, we describe the utilization of micro- and nanotechnologies in applications including drug delivery, tissue engineering, and pharmaceutical development/testing. In addition, we discuss relevant challenges that micro- and nanotechnologies face in achieving cost-effective and widespread clinical implementation as well as forecasted applications of micro- and nanotechnologies in medicine.