Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression
In the tumour microenvironment, cancer cells directly interact with both the immune system and the stroma. It is firmly established that the immune system, historically believed to be a major part of the body's defence against tumour progression, can be reprogrammed by tumour cells to be ineffe...
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| Format: | Article |
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IOP Publishing
2018
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| Online Access: | http://hdl.handle.net/1721.1/119621 https://orcid.org/0000-0001-8462-5080 https://orcid.org/0000-0002-7232-304X |
| _version_ | 1826199425375010816 |
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| author | Seager, R J Zaman, Muhammad H Hajal, Cynthia Spill, Fabian Kamm, Roger Dale |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Seager, R J Zaman, Muhammad H Hajal, Cynthia Spill, Fabian Kamm, Roger Dale |
| author_sort | Seager, R J |
| collection | MIT |
| description | In the tumour microenvironment, cancer cells directly interact with both the immune system and the stroma. It is firmly established that the immune system, historically believed to be a major part of the body's defence against tumour progression, can be reprogrammed by tumour cells to be ineffective, inactivated, or even acquire tumour promoting phenotypes. Likewise, stromal cells and extracellular matrix can also have pro-and anti-tumour properties. However, there is strong evidence that the stroma and immune system also directly interact, therefore creating a tripartite interaction that exists between cancer cells, immune cells and tumour stroma. This interaction contributes to the maintenance of a chronically inflamed tumour microenvironment with pro-tumorigenic immune phenotypes and facilitated metastatic dissemination. A comprehensive understanding of cancer in the context of dynamical interactions of the immune system and the tumour stroma is therefore required to truly understand the progression toward and past malignancy. Keywords: cancer; microenvironment; mechanical; extracellular matrix; macrophage; T cell; fibroblast |
| first_indexed | 2024-09-23T11:20:00Z |
| format | Article |
| id | mit-1721.1/119621 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:20:00Z |
| publishDate | 2018 |
| publisher | IOP Publishing |
| record_format | dspace |
| spelling | mit-1721.1/1196212022-10-01T02:53:39Z Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression Seager, R J Zaman, Muhammad H Hajal, Cynthia Spill, Fabian Kamm, Roger Dale Massachusetts Institute of Technology. Department of Mechanical Engineering Hajal, Cynthia Spill, Fabian Kamm, Roger Dale In the tumour microenvironment, cancer cells directly interact with both the immune system and the stroma. It is firmly established that the immune system, historically believed to be a major part of the body's defence against tumour progression, can be reprogrammed by tumour cells to be ineffective, inactivated, or even acquire tumour promoting phenotypes. Likewise, stromal cells and extracellular matrix can also have pro-and anti-tumour properties. However, there is strong evidence that the stroma and immune system also directly interact, therefore creating a tripartite interaction that exists between cancer cells, immune cells and tumour stroma. This interaction contributes to the maintenance of a chronically inflamed tumour microenvironment with pro-tumorigenic immune phenotypes and facilitated metastatic dissemination. A comprehensive understanding of cancer in the context of dynamical interactions of the immune system and the tumour stroma is therefore required to truly understand the progression toward and past malignancy. Keywords: cancer; microenvironment; mechanical; extracellular matrix; macrophage; T cell; fibroblast National Cancer Institute (U.S.) (Grant U01 CA202177) 2018-12-12T20:09:23Z 2018-12-12T20:09:23Z 2017-07 2017-07 2018-12-05T17:59:08Z Article http://purl.org/eprint/type/JournalArticle 2057-1739 http://hdl.handle.net/1721.1/119621 Seager, R J et al. “Dynamic Interplay Between Tumour, Stroma and Immune System Can Drive or Prevent Tumour Progression.” Convergent Science Physical Oncology 3, 3 (July 2017): 034002 © 2017 IOP Publishing Ltd https://orcid.org/0000-0001-8462-5080 https://orcid.org/0000-0002-7232-304X http://dx.doi.org/10.1088/2057-1739/AA7E86 Convergent Science Physical Oncology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf IOP Publishing arXiv |
| spellingShingle | Seager, R J Zaman, Muhammad H Hajal, Cynthia Spill, Fabian Kamm, Roger Dale Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression |
| title | Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression |
| title_full | Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression |
| title_fullStr | Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression |
| title_full_unstemmed | Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression |
| title_short | Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression |
| title_sort | dynamic interplay between tumour stroma and immune system can drive or prevent tumour progression |
| url | http://hdl.handle.net/1721.1/119621 https://orcid.org/0000-0001-8462-5080 https://orcid.org/0000-0002-7232-304X |
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