Complex mechanics of the heterogeneous extracellular matrix in cancer
The extracellular matrix (ECM) performs many critical functions, one of which is to provide structural and mechanical integrity, and many of the constituent proteins have clear mechanical roles. The composition and structural characteristics of the ECM are widely variable among different tissues, su...
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/119642 https://orcid.org/0000-0002-7019-3907 https://orcid.org/0000-0002-7232-304X |
| _version_ | 1826208939352522752 |
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| author | Malandrino, Andrea Mak, Michael Moeendarbary, Emadaldin Kamm, Roger Dale |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Malandrino, Andrea Mak, Michael Moeendarbary, Emadaldin Kamm, Roger Dale |
| author_sort | Malandrino, Andrea |
| collection | MIT |
| description | The extracellular matrix (ECM) performs many critical functions, one of which is to provide structural and mechanical integrity, and many of the constituent proteins have clear mechanical roles. The composition and structural characteristics of the ECM are widely variable among different tissues, suiting diverse functional needs. In diseased tissues, particularly solid tumors, the ECM is complex and influences disease progression. Cancer and stromal cells can significantly influence the matrix composition and structure and thus the mechanical properties of the tumor microenvironment (TME). In this review, we describe the interactions that give rise to the structural heterogeneity of the ECM and present the techniques that are widely employed to measure ECM properties and remodeling dynamics. Furthermore, we review the tools for measuring the distinct nature of cell–ECM interactions within the TME. |
| first_indexed | 2024-09-23T14:15:08Z |
| format | Article |
| id | mit-1721.1/119642 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:15:08Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1196422024-07-12T16:35:16Z Complex mechanics of the heterogeneous extracellular matrix in cancer Malandrino, Andrea Mak, Michael Moeendarbary, Emadaldin Kamm, Roger Dale Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Moeendarbary, Emadaldin Kamm, Roger Dale The extracellular matrix (ECM) performs many critical functions, one of which is to provide structural and mechanical integrity, and many of the constituent proteins have clear mechanical roles. The composition and structural characteristics of the ECM are widely variable among different tissues, suiting diverse functional needs. In diseased tissues, particularly solid tumors, the ECM is complex and influences disease progression. Cancer and stromal cells can significantly influence the matrix composition and structure and thus the mechanical properties of the tumor microenvironment (TME). In this review, we describe the interactions that give rise to the structural heterogeneity of the ECM and present the techniques that are widely employed to measure ECM properties and remodeling dynamics. Furthermore, we review the tools for measuring the distinct nature of cell–ECM interactions within the TME. National Cancer Institute (U.S.) (U01 CA202177-01) 2018-12-13T19:24:56Z 2018-12-13T19:24:56Z 2018-05 2018-02 2018-12-05T18:27:38Z Article http://purl.org/eprint/type/JournalArticle 2352-4316 http://hdl.handle.net/1721.1/119642 Malandrino, Andrea, Michael Mak, Roger D. Kamm, and Emad Moeendarbary. “Complex Mechanics of the Heterogeneous Extracellular Matrix in Cancer.” Extreme Mechanics Letters 21 (May 2018): 25–34. © 2018 The Authors https://orcid.org/0000-0002-7019-3907 https://orcid.org/0000-0002-7232-304X http://dx.doi.org/10.1016/J.EML.2018.02.003 Extreme Mechanics Letters Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Malandrino, Andrea Mak, Michael Moeendarbary, Emadaldin Kamm, Roger Dale Complex mechanics of the heterogeneous extracellular matrix in cancer |
| title | Complex mechanics of the heterogeneous extracellular matrix in cancer |
| title_full | Complex mechanics of the heterogeneous extracellular matrix in cancer |
| title_fullStr | Complex mechanics of the heterogeneous extracellular matrix in cancer |
| title_full_unstemmed | Complex mechanics of the heterogeneous extracellular matrix in cancer |
| title_short | Complex mechanics of the heterogeneous extracellular matrix in cancer |
| title_sort | complex mechanics of the heterogeneous extracellular matrix in cancer |
| url | http://hdl.handle.net/1721.1/119642 https://orcid.org/0000-0002-7019-3907 https://orcid.org/0000-0002-7232-304X |
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