Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition

Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition

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Introduction: Targeted cancer therapeutics have demonstrated more limited clinical efficacy than anticipated, due to both intrinsic and acquired drug resistance. Underlying mechanisms have been largely attributed to genetic changes, but a substantial proportion of resistance observations remain unex...

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Podrobná bibliografie
Hlavní autoři: Meyer, Aaron S., Claas, Allison Mary, Atta, Lyla H., Gordonov, Simon
Další autoři: Massachusetts Institute of Technology. Department of Biological Engineering
Médium: Článek
Jazyk:English
Vydáno: Springer US 2018
On-line přístup:http://hdl.handle.net/1721.1/119648
https://orcid.org/0000-0003-1224-8153
https://orcid.org/0000-0001-6284-2711

Internet

http://hdl.handle.net/1721.1/119648
https://orcid.org/0000-0003-1224-8153
https://orcid.org/0000-0001-6284-2711

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