Integrated experimental and computational analysis of intercellular communication with application to endometriosis
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2018.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2019
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| Online Access: | http://hdl.handle.net/1721.1/119971 |
| _version_ | 1811079562544545792 |
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| author | Hill, Abby Shuman |
| author2 | Douglas A. Lauffenburger. |
| author_facet | Douglas A. Lauffenburger. Hill, Abby Shuman |
| author_sort | Hill, Abby Shuman |
| collection | MIT |
| description | Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2018. |
| first_indexed | 2024-09-23T11:16:41Z |
| format | Thesis |
| id | mit-1721.1/119971 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:16:41Z |
| publishDate | 2019 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1199712019-04-12T11:31:21Z Integrated experimental and computational analysis of intercellular communication with application to endometriosis Hill, Abby Shuman Douglas A. Lauffenburger. Massachusetts Institute of Technology. Department of Biological Engineering. Massachusetts Institute of Technology. Department of Biological Engineering. Biological Engineering. Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2018. Cataloged from PDF version of thesis. Includes bibliographical references (pages 143-162). Cell-cell communication is critically important to the function of the immune system, allowing a systems-level determination of the appropriate type of immune response to a perturbation. The immune system has at its disposal multiple types of responses, some beneficial and others harmful, all of which require coordination among immune cells and between the immune system and non-immune tissue cells. In this thesis, we have explored the use of multiple experimental and computational methods to understand how intercellular communication shapes the immune response in health and disease. Applications of this work are primarily focused on endometriosis, a disease characterized by the presence of endometrial glands and stroma located outside of the uterus. Disease initiation (cell survival) and progression (including neovascularization and neurogenesis) are thought to depend on interactions with the immune system, particularly macrophages. We have investigated these interactions on several levels, using both clinical samples and 3D in vitro culture models. The model systems used here include endometrial stromal and epithelial cells as well as peripheral blood monocytes with which to study dynamic processes within either the eutopic endometrium or the endometriotic lesion environment. by Abby Shuman Hill. Ph. D. 2019-01-11T16:06:24Z 2019-01-11T16:06:24Z 2018 2018 Thesis http://hdl.handle.net/1721.1/119971 1080639262 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 162 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biological Engineering. Hill, Abby Shuman Integrated experimental and computational analysis of intercellular communication with application to endometriosis |
| title | Integrated experimental and computational analysis of intercellular communication with application to endometriosis |
| title_full | Integrated experimental and computational analysis of intercellular communication with application to endometriosis |
| title_fullStr | Integrated experimental and computational analysis of intercellular communication with application to endometriosis |
| title_full_unstemmed | Integrated experimental and computational analysis of intercellular communication with application to endometriosis |
| title_short | Integrated experimental and computational analysis of intercellular communication with application to endometriosis |
| title_sort | integrated experimental and computational analysis of intercellular communication with application to endometriosis |
| topic | Biological Engineering. |
| url | http://hdl.handle.net/1721.1/119971 |
| work_keys_str_mv | AT hillabbyshuman integratedexperimentalandcomputationalanalysisofintercellularcommunicationwithapplicationtoendometriosis |