Surface functionalization in combination with confinement for crystallization from undersaturated solutions
Crystallization from undersaturated solutions was demonstrated using functionalized nanoporous silica (Zorbax® chromatographic media). The silica matrix acts as a source of bound groups within the nanopores which act to reduce the solubility within the small pore volume resulting in the formation of...
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| Format: | Article |
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Royal Society of Chemistry
2019
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| Online Access: | http://hdl.handle.net/1721.1/120286 https://orcid.org/0000-0001-5125-1051 https://orcid.org/0000-0002-7596-3595 https://orcid.org/0000-0002-7468-8093 |
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| author | Vartak, Shankul Shisheer Dwyer, Leia Mary Myerson, Allan S. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Vartak, Shankul Shisheer Dwyer, Leia Mary Myerson, Allan S. |
| author_sort | Vartak, Shankul Shisheer |
| collection | MIT |
| description | Crystallization from undersaturated solutions was demonstrated using functionalized nanoporous silica (Zorbax® chromatographic media). The silica matrix acts as a source of bound groups within the nanopores which act to reduce the solubility within the small pore volume resulting in the formation of nanocrystals within the pores. Experiments were conducted within sealed capillaries which were monitored via X-ray powder diffraction. Experiments were conducted for a number of solutes and concentrations and clearly demonstrated a critical concentration in the undersaturated region below which crystals would not form. Concentrations above this critical concentration would form crystals. Batch experiments confirmed that the crystallization yield could be calculated from the difference between the initial concentration before the addition of Zorbax® and the critical (effective saturation) concentration. |
| first_indexed | 2024-09-23T14:36:16Z |
| format | Article |
| id | mit-1721.1/120286 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:36:16Z |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | mit-1721.1/1202862022-09-29T09:55:53Z Surface functionalization in combination with confinement for crystallization from undersaturated solutions Vartak, Shankul Shisheer Dwyer, Leia Mary Myerson, Allan S. Massachusetts Institute of Technology. Department of Chemical Engineering Vartak, Shankul Shisheer Dwyer, Leia Mary Myerson, Allan S. Crystallization from undersaturated solutions was demonstrated using functionalized nanoporous silica (Zorbax® chromatographic media). The silica matrix acts as a source of bound groups within the nanopores which act to reduce the solubility within the small pore volume resulting in the formation of nanocrystals within the pores. Experiments were conducted within sealed capillaries which were monitored via X-ray powder diffraction. Experiments were conducted for a number of solutes and concentrations and clearly demonstrated a critical concentration in the undersaturated region below which crystals would not form. Concentrations above this critical concentration would form crystals. Batch experiments confirmed that the crystallization yield could be calculated from the difference between the initial concentration before the addition of Zorbax® and the critical (effective saturation) concentration. United States. Defense Advanced Research Projects Agency (Grant W911NF-16-2-0023) Novartis-MIT Center for Continuous Manufacturing 2019-02-08T15:43:02Z 2019-02-08T15:43:02Z 2018-10 2018-09 2018-12-06T13:58:39Z Article http://purl.org/eprint/type/JournalArticle 1466-8033 http://hdl.handle.net/1721.1/120286 Vartak, Shankul, Leia M. Dwyer, and Allan S. Myerson. “Surface Functionalization in Combination with Confinement for Crystallization from Undersaturated Solutions.” CrystEngComm 20, no. 40 (2018): 6136–6139. © 2018 The Royal Society of Chemistry https://orcid.org/0000-0001-5125-1051 https://orcid.org/0000-0002-7596-3595 https://orcid.org/0000-0002-7468-8093 http://dx.doi.org/10.1039/c8ce01543k CrystEngComm Creative Commons Attribution 3.0 Unported license http://creativecommons.org/licenses/by/3.0/ application/pdf Royal Society of Chemistry Royal Society of Chemistry |
| spellingShingle | Vartak, Shankul Shisheer Dwyer, Leia Mary Myerson, Allan S. Surface functionalization in combination with confinement for crystallization from undersaturated solutions |
| title | Surface functionalization in combination with confinement for crystallization from undersaturated solutions |
| title_full | Surface functionalization in combination with confinement for crystallization from undersaturated solutions |
| title_fullStr | Surface functionalization in combination with confinement for crystallization from undersaturated solutions |
| title_full_unstemmed | Surface functionalization in combination with confinement for crystallization from undersaturated solutions |
| title_short | Surface functionalization in combination with confinement for crystallization from undersaturated solutions |
| title_sort | surface functionalization in combination with confinement for crystallization from undersaturated solutions |
| url | http://hdl.handle.net/1721.1/120286 https://orcid.org/0000-0001-5125-1051 https://orcid.org/0000-0002-7596-3595 https://orcid.org/0000-0002-7468-8093 |
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