Chromatin organization by an interplay of loop extrusion and compartmental segregation

Mammalian chromatin is spatially organized at many scales showing two prominent features in interphase: (i) alternating regions (1–10 Mb) of active and inactive chromatin that spatially segregate into different compartments, and (II) domains (<1 Mb), that is, regions that preferentially interact...

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Bibliographic Details
Main Authors: Fudenberg, Geoffrey, Nubler, Johannes, Imakaev, Maksim Viktorovich, Abdennur, Nezar Alexander, Mirny, Leonid A
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: National Academy of Sciences (U.S.) 2019
Online Access:http://hdl.handle.net/1721.1/120590
https://orcid.org/0000-0002-5320-2728
https://orcid.org/0000-0001-5814-0864
https://orcid.org/0000-0002-0785-5410