Chromatin organization by an interplay of loop extrusion and compartmental segregation
Mammalian chromatin is spatially organized at many scales showing two prominent features in interphase: (i) alternating regions (1–10 Mb) of active and inactive chromatin that spatially segregate into different compartments, and (II) domains (<1 Mb), that is, regions that preferentially interact...
Main Authors: | Fudenberg, Geoffrey, Nubler, Johannes, Imakaev, Maksim Viktorovich, Abdennur, Nezar Alexander, Mirny, Leonid A |
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Other Authors: | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
Format: | Article |
Published: |
National Academy of Sciences (U.S.)
2019
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Online Access: | http://hdl.handle.net/1721.1/120590 https://orcid.org/0000-0002-5320-2728 https://orcid.org/0000-0001-5814-0864 https://orcid.org/0000-0002-0785-5410 |
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