Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response
Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C. elegans mediates its response to both osmotic stress and starvation. We report that in respo...
| Main Authors: | , , , , , |
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| Format: | Article |
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Nature Publishing Group
2019
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| Online Access: | http://hdl.handle.net/1721.1/120928 https://orcid.org/0000-0002-1370-9460 https://orcid.org/0000-0002-0608-1230 https://orcid.org/0000-0002-0573-3380 https://orcid.org/0000-0002-9964-9613 |
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| author | Burton, Nicholas O Dwivedi, Vivek Kumar Burkhart, Kirk Benjamin Kaplan, Rebecca D. Baugh, Lauren Horvitz, Howard Robert |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Burton, Nicholas O Dwivedi, Vivek Kumar Burkhart, Kirk Benjamin Kaplan, Rebecca D. Baugh, Lauren Horvitz, Howard Robert |
| author_sort | Burton, Nicholas O |
| collection | MIT |
| description | Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C. elegans mediates its response to both osmotic stress and starvation. We report that in response to osmotic stress the cytosolic sulfotransferase SSU-1 antagonizes insulin-like signaling and promotes developmental arrest. Both SSU-1 and the DAF-16 FOXO transcription factor, which is activated when insulin signaling is low, are needed to drive specific responses to reduced insulin-like signaling. We demonstrate that SSU-1 functions in a single pair of sensory neurons to control intercellular signaling via the nuclear hormone receptor NHR-1 and promote both the specific transcriptional response to osmotic stress and altered lysophosphatidylcholine metabolism. Our results show the requirement of a sulfotransferase–nuclear hormone receptor neurohormonal signaling pathway for some but not all consequences of reduced insulin-like signaling. |
| first_indexed | 2024-09-23T10:21:12Z |
| format | Article |
| id | mit-1721.1/120928 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:21:12Z |
| publishDate | 2019 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1209282022-09-30T20:35:33Z Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response Burton, Nicholas O Dwivedi, Vivek Kumar Burkhart, Kirk Benjamin Kaplan, Rebecca D. Baugh, Lauren Horvitz, Howard Robert Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Burton, Nicholas O Dwivedi, Vivek Kumar Burkhart, Kirk Benjamin Kaplan, Rebecca D. Baugh, Lauren Horvitz, Howard Robert Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C. elegans mediates its response to both osmotic stress and starvation. We report that in response to osmotic stress the cytosolic sulfotransferase SSU-1 antagonizes insulin-like signaling and promotes developmental arrest. Both SSU-1 and the DAF-16 FOXO transcription factor, which is activated when insulin signaling is low, are needed to drive specific responses to reduced insulin-like signaling. We demonstrate that SSU-1 functions in a single pair of sensory neurons to control intercellular signaling via the nuclear hormone receptor NHR-1 and promote both the specific transcriptional response to osmotic stress and altered lysophosphatidylcholine metabolism. Our results show the requirement of a sulfotransferase–nuclear hormone receptor neurohormonal signaling pathway for some but not all consequences of reduced insulin-like signaling. National Center for Research Resources (U.S.) National Institutes of Health (U.S.) (grant GM024663) National Science Foundation (U.S.) (grant 1122374) University of Cambridge. Centre for Trophoblast Research (Next Generation Fellowship) National Institutes of Health (U.S.) (grant GM117408) 2019-03-12T17:51:21Z 2019-03-12T17:51:21Z 2018-12 2018-05 2019-03-04T14:49:18Z Article http://purl.org/eprint/type/JournalArticle 2041-1723 http://hdl.handle.net/1721.1/120928 Burton, Nicholas O., Vivek K. Dwivedi, Kirk B. Burkhart, Rebecca E. W. Kaplan, L. Ryan Baugh, and H. Robert Horvitz. “Neurohormonal Signaling via a Sulfotransferase Antagonizes Insulin-Like Signaling to Regulate a Caenorhabditis Elegans Stress Response.” Nature Communications 9, no. 1 (December 2018). https://orcid.org/0000-0002-1370-9460 https://orcid.org/0000-0002-0608-1230 https://orcid.org/0000-0002-0573-3380 https://orcid.org/0000-0002-9964-9613 http://dx.doi.org/10.1038/s41467-018-07640-w Nature Communications Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature |
| spellingShingle | Burton, Nicholas O Dwivedi, Vivek Kumar Burkhart, Kirk Benjamin Kaplan, Rebecca D. Baugh, Lauren Horvitz, Howard Robert Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response |
| title | Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response |
| title_full | Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response |
| title_fullStr | Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response |
| title_full_unstemmed | Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response |
| title_short | Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response |
| title_sort | neurohormonal signaling via a sulfotransferase antagonizes insulin like signaling to regulate a caenorhabditis elegans stress response |
| url | http://hdl.handle.net/1721.1/120928 https://orcid.org/0000-0002-1370-9460 https://orcid.org/0000-0002-0608-1230 https://orcid.org/0000-0002-0573-3380 https://orcid.org/0000-0002-9964-9613 |
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