Hsp70–Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation
Protein abnormalities in cells are the cause of major pathologies, and a number of adaptive responses have evolved to relieve the toxicity of misfolded polypeptides. To trigger these responses, cells must detect the buildup of aberrant proteins which often associate with proteasome failure, but the...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
National Academy of Sciences
2019
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| Online Access: | http://hdl.handle.net/1721.1/121003 https://orcid.org/0000-0002-2819-5570 https://orcid.org/0000-0002-8764-1809 |