INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY
Purpose—To report on a posterior segment coloboma manifesting unusual morphology as determined by high-speed, ultrahigh resolution optical coherence tomography imaging (hsUHROCT). Methods—A 47-year-old patient with bilateral colobomas was evaluated via fundus examination and hsUHR-OCT. Results—I...
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| Format: | Article |
| Language: | en_US |
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Ovid Technologies (Wolters Kluwer Health)
2019
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| Online Access: | https://hdl.handle.net/1721.1/121158 |
| _version_ | 1811076224642973696 |
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| author | Judson, Christopher H Vuong, Laurel N. Gorczynska, Iwona M Srinivasan, Vivek J. Fujimoto, James G Duker, Jay S |
| author2 | Massachusetts Institute of Technology. Research Laboratory of Electronics |
| author_facet | Massachusetts Institute of Technology. Research Laboratory of Electronics Judson, Christopher H Vuong, Laurel N. Gorczynska, Iwona M Srinivasan, Vivek J. Fujimoto, James G Duker, Jay S |
| author_sort | Judson, Christopher H |
| collection | MIT |
| description | Purpose—To report on a posterior segment coloboma manifesting unusual morphology as
determined by high-speed, ultrahigh resolution optical coherence tomography imaging (hsUHROCT).
Methods—A 47-year-old patient with bilateral colobomas was evaluated via fundus examination
and hsUHR-OCT.
Results—Imaging with hsUHR-OCT showed intact retinal pigment epithelium (RPE) within the
posterior segment coloboma. Most of the retinal layers appeared to continue into the coloboma,
although they exhibited slight attenuation. The external limiting membrane (ELM) was clearly
visible continuing within the coloboma, suggesting that Muller cells and the inner segments of the
photoreceptors were still present in this area. The junction between the inner and outer segments
of the photoreceptors ended at the margin of the coloboma, which may be due to either
photoreceptor disruption or a change in the orientation of the outer segments.
Conclusion—hsUHR-OCT demonstrated the presence of Muller cells and photoreceptor inner
segments within a posterior segment coloboma. The retinal pigment epithelium (RPE) was intact
within the coloboma, representing an unusual morphology. |
| first_indexed | 2024-09-23T10:18:15Z |
| format | Article |
| id | mit-1721.1/121158 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:18:15Z |
| publishDate | 2019 |
| publisher | Ovid Technologies (Wolters Kluwer Health) |
| record_format | dspace |
| spelling | mit-1721.1/1211582022-09-26T17:07:08Z INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY Judson, Christopher H Vuong, Laurel N. Gorczynska, Iwona M Srinivasan, Vivek J. Fujimoto, James G Duker, Jay S Massachusetts Institute of Technology. Research Laboratory of Electronics Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Fujimoto, James G. Purpose—To report on a posterior segment coloboma manifesting unusual morphology as determined by high-speed, ultrahigh resolution optical coherence tomography imaging (hsUHROCT). Methods—A 47-year-old patient with bilateral colobomas was evaluated via fundus examination and hsUHR-OCT. Results—Imaging with hsUHR-OCT showed intact retinal pigment epithelium (RPE) within the posterior segment coloboma. Most of the retinal layers appeared to continue into the coloboma, although they exhibited slight attenuation. The external limiting membrane (ELM) was clearly visible continuing within the coloboma, suggesting that Muller cells and the inner segments of the photoreceptors were still present in this area. The junction between the inner and outer segments of the photoreceptors ended at the margin of the coloboma, which may be due to either photoreceptor disruption or a change in the orientation of the outer segments. Conclusion—hsUHR-OCT demonstrated the presence of Muller cells and photoreceptor inner segments within a posterior segment coloboma. The retinal pigment epithelium (RPE) was intact within the coloboma, representing an unusual morphology. National Institutes of Health (U.S.) (Grant R01-EY11289-21) United States. Air Force Office of Scientific Research (Contract FA9550-07-1-0101) 2019-05-07T20:40:07Z 2019-05-07T20:40:07Z 2011-01 Article http://purl.org/eprint/type/JournalArticle 1935-1089 https://hdl.handle.net/1721.1/121158 Judson, Christopher H et al. “INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY.” Retinal Cases & Brief Reports 5.1 (2011): 46-48. en_US 10.1097/icb.0b013e3181cafc49 Retinal Cases & Brief Reports Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Ovid Technologies (Wolters Kluwer Health) PubMed Central |
| spellingShingle | Judson, Christopher H Vuong, Laurel N. Gorczynska, Iwona M Srinivasan, Vivek J. Fujimoto, James G Duker, Jay S INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY |
| title | INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY |
| title_full | INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY |
| title_fullStr | INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY |
| title_full_unstemmed | INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY |
| title_short | INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY |
| title_sort | intact retinal tissue and retinal pigment epithelium identified within a coloboma by high speed ultrahigh resolution optical coherence tomography |
| url | https://hdl.handle.net/1721.1/121158 |
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