Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation

Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation

We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues from the Genotype-Tissue Expression project and genome-wide association study data. About 60% of known trait-associated loci are in linkage disequilibrium with a cis-eQTL, over half of which were not found in pre...

Full description

Bibliographic Details
Main Authors: Gamazon, Eric R., Segrè, Ayellet V., van de Bunt, Martijn, Wen, Xiaoquan, Xi, Hualin S., Hormozdiari, Farhad, Ongen, Halit, Konkashbaev, Anuar, Derks, Eske M., Aguet, François, Quan, Jie, GTEx Consortium, Nicolae, Dan L., Eskin, Eleazar, Kamvysselis, Manolis, Getz, Gad, McCarthy, Mark I., Dermitzakis, Emmanouil T., Cox, Nancy J., Ardlie, Kristin G.
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:English
Published: Springer Nature 2019
Online Access:https://hdl.handle.net/1721.1/121227

Similar Items

Similar Items