Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study
Background--Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin-cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Ovid Technologies (Wolters Kluwer Health)
2019
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| Online Access: | https://hdl.handle.net/1721.1/121408 |
| _version_ | 1826198008512905216 |
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| author | Minami, Yoshiyasu Wang, Zhao Aguirre, Aaron D. Ong, Daniel S. Kim, Chong‐Jin Uemura, Shiro Soeda, Tsunenari Lee, Hang Fujimoto, James Jang, Ik‐Kyung |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Minami, Yoshiyasu Wang, Zhao Aguirre, Aaron D. Ong, Daniel S. Kim, Chong‐Jin Uemura, Shiro Soeda, Tsunenari Lee, Hang Fujimoto, James Jang, Ik‐Kyung |
| author_sort | Minami, Yoshiyasu |
| collection | MIT |
| description | Background--Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin-cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. Methods and Results--A total of 140 nonculprit plaques from 84 patients with coronary artery disease who were treated with a statin and had serial optical coherence tomography imaging (median interval, 6.3 months) were included. Thin-cap area (fibrous cap thickness, < 200 μm) was measured using a novel 3-dimensional computer-aided algorithm. Overall, the thin-cap area significantly decreased from baseline (median, 2.852 mm2; 25th-75th percentile, 1.023-6.157 mm2) to follow-up (median, 1.210 mm2; 25th-75th percentile, 0.250-3.192 mm2; P < 0.001), and low-density lipoprotein cholesterol significantly decreased from baseline (mean±SD, 92.9±30.1 mg/dL) to follow-up (mean±SD, 76.3±23.3 mg/dL; P < 0.001). The general linear model with multiple predictor variables revealed that the thin-cap area was significantly higher in patients with chronic kidney disease than in those without it (regression coefficient b, 1.691 mm2; 95% confidence interval, 0.350-3.033 mm2; P=0.013) and lower in patients with acute coronary syndrome (regression coefficient b, -1.535 mm2; 95% confidence interval, -2.561 to -0.509 mm2; P=0.003). Conclusions--Chronic kidney disease is an independent predictor for the lack of a favorable vascular response to statin therapy, whereas acute coronary syndrome is an independent predictor for favorable vascular response to statin therapy. These findings should be further warranted in future prospective studies. Keywords: atherosclerosis; fibrous cap; optical coherence tomography; statin therapy; coronary artery disease |
| first_indexed | 2024-09-23T10:57:26Z |
| format | Article |
| id | mit-1721.1/121408 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:57:26Z |
| publishDate | 2019 |
| publisher | Ovid Technologies (Wolters Kluwer Health) |
| record_format | dspace |
| spelling | mit-1721.1/1214082022-10-01T00:13:48Z Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study Minami, Yoshiyasu Wang, Zhao Aguirre, Aaron D. Ong, Daniel S. Kim, Chong‐Jin Uemura, Shiro Soeda, Tsunenari Lee, Hang Fujimoto, James Jang, Ik‐Kyung Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Background--Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin-cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. Methods and Results--A total of 140 nonculprit plaques from 84 patients with coronary artery disease who were treated with a statin and had serial optical coherence tomography imaging (median interval, 6.3 months) were included. Thin-cap area (fibrous cap thickness, < 200 μm) was measured using a novel 3-dimensional computer-aided algorithm. Overall, the thin-cap area significantly decreased from baseline (median, 2.852 mm2; 25th-75th percentile, 1.023-6.157 mm2) to follow-up (median, 1.210 mm2; 25th-75th percentile, 0.250-3.192 mm2; P < 0.001), and low-density lipoprotein cholesterol significantly decreased from baseline (mean±SD, 92.9±30.1 mg/dL) to follow-up (mean±SD, 76.3±23.3 mg/dL; P < 0.001). The general linear model with multiple predictor variables revealed that the thin-cap area was significantly higher in patients with chronic kidney disease than in those without it (regression coefficient b, 1.691 mm2; 95% confidence interval, 0.350-3.033 mm2; P=0.013) and lower in patients with acute coronary syndrome (regression coefficient b, -1.535 mm2; 95% confidence interval, -2.561 to -0.509 mm2; P=0.003). Conclusions--Chronic kidney disease is an independent predictor for the lack of a favorable vascular response to statin therapy, whereas acute coronary syndrome is an independent predictor for favorable vascular response to statin therapy. These findings should be further warranted in future prospective studies. Keywords: atherosclerosis; fibrous cap; optical coherence tomography; statin therapy; coronary artery disease 2019-06-25T16:58:12Z 2019-06-25T16:58:12Z 2017-11 2017-03 2019-06-21T18:20:39Z Article http://purl.org/eprint/type/JournalArticle 2047-9980 https://hdl.handle.net/1721.1/121408 Minami, Yoshiyasu et al. "Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study." Journal of the American Heart Association 6, 11 (September 2017) © 2017 The Authors en http://dx.doi.org/10.1161/jaha.117.006241 Journal of the American Heart Association Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf Ovid Technologies (Wolters Kluwer Health) American Heart Association |
| spellingShingle | Minami, Yoshiyasu Wang, Zhao Aguirre, Aaron D. Ong, Daniel S. Kim, Chong‐Jin Uemura, Shiro Soeda, Tsunenari Lee, Hang Fujimoto, James Jang, Ik‐Kyung Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study |
| title | Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study |
| title_full | Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study |
| title_fullStr | Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study |
| title_full_unstemmed | Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study |
| title_short | Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study |
| title_sort | clinical predictors for lack of favorable vascular response to statin therapy in patients with coronary artery disease a serial optical coherence tomography study |
| url | https://hdl.handle.net/1721.1/121408 |
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