Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis
Purpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis...
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Association for Research in Vision and Ophthalmology (ARVO)
2019
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| Online Access: | https://hdl.handle.net/1721.1/121496 |
| _version_ | 1826206140956934144 |
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| author | Rebhun, Carl B. Moult, Eric Michael Novais, Eduardo Moreira-Neto, Carlos Ploner, Stefan B Louzada, Ricardo N. Lee, Byungkun Baumal, Caroline R. Fujimoto, James G Duker, Jay S. Waheed, Nadia K. Ferrara, Daniela |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Rebhun, Carl B. Moult, Eric Michael Novais, Eduardo Moreira-Neto, Carlos Ploner, Stefan B Louzada, Ricardo N. Lee, Byungkun Baumal, Caroline R. Fujimoto, James G Duker, Jay S. Waheed, Nadia K. Ferrara, Daniela |
| author_sort | Rebhun, Carl B. |
| collection | MIT |
| description | Purpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by indocyanine-green angiography (ICGA). The relative blood flow speeds were characterized on VISTAOCTA. Results: Seven eyes from seven patients were evaluated. Swept-source OCTA enabled detailed enface visualization of the BVN and polyps in six eyes. VISTA-OCTA revealed variable blood flow speeds in different PCV lesion components of the same eye, with faster flow in the periphery of polyps and slower flow in the center of each polyp, as well as relatively slow flow in BVN when compared with retinal vessels. BVNs demonstrated relatively faster blood flow speeds in the larger trunk vessels and relatively slower speeds in the smaller vessels. Conclusions: Swept-source OCTA identifies polyps in most, but not all, PCV lesions. This limitation that may be related to relatively slow blood flow within the polyp, which may be below the OCTA’s sensitivity. VISTA-OCTA showed heterogeneous blood flow speeds within the polyps, which may indicate turbulent flow in the polyps. Translational Relevance: These results bring relevant insights into disease mechanisms that can account for the variable course of PCV, and can be relevant for diagnosis and management of patients with PCV. Keywords: OCTA; optical coherence tomography angiography; PCV; polypoidal choroidal vasculopathy; variable interscan time analysis |
| first_indexed | 2024-09-23T13:24:44Z |
| format | Article |
| id | mit-1721.1/121496 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:24:44Z |
| publishDate | 2019 |
| publisher | Association for Research in Vision and Ophthalmology (ARVO) |
| record_format | dspace |
| spelling | mit-1721.1/1214962022-10-01T15:06:56Z Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis Rebhun, Carl B. Moult, Eric Michael Novais, Eduardo Moreira-Neto, Carlos Ploner, Stefan B Louzada, Ricardo N. Lee, Byungkun Baumal, Caroline R. Fujimoto, James G Duker, Jay S. Waheed, Nadia K. Ferrara, Daniela Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Massachusetts Institute of Technology. Institute for Medical Engineering & Science Purpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by indocyanine-green angiography (ICGA). The relative blood flow speeds were characterized on VISTAOCTA. Results: Seven eyes from seven patients were evaluated. Swept-source OCTA enabled detailed enface visualization of the BVN and polyps in six eyes. VISTA-OCTA revealed variable blood flow speeds in different PCV lesion components of the same eye, with faster flow in the periphery of polyps and slower flow in the center of each polyp, as well as relatively slow flow in BVN when compared with retinal vessels. BVNs demonstrated relatively faster blood flow speeds in the larger trunk vessels and relatively slower speeds in the smaller vessels. Conclusions: Swept-source OCTA identifies polyps in most, but not all, PCV lesions. This limitation that may be related to relatively slow blood flow within the polyp, which may be below the OCTA’s sensitivity. VISTA-OCTA showed heterogeneous blood flow speeds within the polyps, which may indicate turbulent flow in the polyps. Translational Relevance: These results bring relevant insights into disease mechanisms that can account for the variable course of PCV, and can be relevant for diagnosis and management of patients with PCV. Keywords: OCTA; optical coherence tomography angiography; PCV; polypoidal choroidal vasculopathy; variable interscan time analysis National Institutes of Health (U.S.) (Grant R01-EY011289-29A) National Institutes of Health (U.S.) (Grant R44- EY022864) National Institutes of Health (U.S.) (Grant R01-CA075289-16) Air Force Office of Scientific Research (Grant FA9550-15-1-0473) Air Force Office of Scientific Research (Grant FA9550-12-1-0499) 2019-07-05T15:40:43Z 2019-07-05T15:40:43Z 2017-11 2017-06 2019-06-26T15:48:46Z Article http://purl.org/eprint/type/JournalArticle 2164-2591 https://hdl.handle.net/1721.1/121496 Rebhun, Carl B. et al. "Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis." Translational Vision Science & Technology 6, 6 (November 2017): 4 © 2017 The Authors en http://dx.doi.org/10.1167/TVST.6.6.4 Translational Vision Science & Technology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Association for Research in Vision and Ophthalmology (ARVO) Association for Research in Vision and Ophthalmology (ARVO) |
| spellingShingle | Rebhun, Carl B. Moult, Eric Michael Novais, Eduardo Moreira-Neto, Carlos Ploner, Stefan B Louzada, Ricardo N. Lee, Byungkun Baumal, Caroline R. Fujimoto, James G Duker, Jay S. Waheed, Nadia K. Ferrara, Daniela Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis |
| title | Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis |
| title_full | Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis |
| title_fullStr | Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis |
| title_full_unstemmed | Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis |
| title_short | Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis |
| title_sort | polypoidal choroidal vasculopathy on swept source optical coherence tomography angiography with variable interscan time analysis |
| url | https://hdl.handle.net/1721.1/121496 |
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